Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange.
Alveolar recruitment
Blood gas
Capnography
Gas exchange
Lung ventilation
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
15 Oct 2022
15 Oct 2022
Historique:
received:
02
06
2022
accepted:
06
10
2022
entrez:
15
10
2022
pubmed:
16
10
2022
medline:
19
10
2022
Statut:
epublish
Résumé
Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified percussive ventilation modality created by superimposing high-frequency oscillations to the conventional ventilation waveform during expiration only (eHFPV) with conventional mechanical ventilation (CMV) and standard HFPV. Hypoxia and hypercapnia were induced by decreasing the frequency of CMV in New Zealand White rabbits (n = 10). Following steady-state CMV periods, percussive modalities with oscillations randomly introduced to the entire breathing cycle (HFPV) or to the expiratory phase alone (eHFPV) with varying amplitudes (2 or 4 cmH The use of eHFPV with 5 Hz superimposed oscillation frequency and an amplitude of 4 cmH These findings demonstrated improved gas exchange using eHFPV as a novel mechanical ventilation modality that combines the benefits of conventional and small-amplitude high-frequency oscillatory ventilation, owing to improved longitudinal gas transport rather than increased lung surface area available for gas exchange.
Sections du résumé
BACKGROUND
BACKGROUND
Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified percussive ventilation modality created by superimposing high-frequency oscillations to the conventional ventilation waveform during expiration only (eHFPV) with conventional mechanical ventilation (CMV) and standard HFPV.
METHODS
METHODS
Hypoxia and hypercapnia were induced by decreasing the frequency of CMV in New Zealand White rabbits (n = 10). Following steady-state CMV periods, percussive modalities with oscillations randomly introduced to the entire breathing cycle (HFPV) or to the expiratory phase alone (eHFPV) with varying amplitudes (2 or 4 cmH
RESULTS
RESULTS
The use of eHFPV with 5 Hz superimposed oscillation frequency and an amplitude of 4 cmH
CONCLUSIONS
CONCLUSIONS
These findings demonstrated improved gas exchange using eHFPV as a novel mechanical ventilation modality that combines the benefits of conventional and small-amplitude high-frequency oscillatory ventilation, owing to improved longitudinal gas transport rather than increased lung surface area available for gas exchange.
Identifiants
pubmed: 36243752
doi: 10.1186/s12931-022-02215-2
pii: 10.1186/s12931-022-02215-2
pmc: PMC9569091
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
283Subventions
Organisme : Hungarian Science Foundation
ID : OTKA-NKFIH K138032
Informations de copyright
© 2022. The Author(s).
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