Disentangling the Relationships Between the Clinical Symptoms of Schizophrenia Spectrum Disorders and Theory of Mind: A Meta-analysis.
Cognitive/Disorganization symptoms
mentalizing
negative symptoms
positive symptoms
social cognition
Journal
Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760
Informations de publication
Date de publication:
15 03 2023
15 03 2023
Historique:
pubmed:
17
10
2022
medline:
21
3
2023
entrez:
16
10
2022
Statut:
ppublish
Résumé
Previous studies have suggested links between clinical symptoms and theory of mind (ToM) impairments in schizophrenia spectrum disorders (SSD), but it remains unclear whether some symptoms are more strongly linked to ToM than others. A meta-analysis (Prospero; CRD42021259723) was conducted to quantify and compare the strength of the associations between ToM and the clinical symptoms of SSD (Positive, Negative, Cognitive/Disorganization, Depression/Anxiety, Excitability/Hostility). Studies (N = 130, 137 samples) including people with SSD and reporting a correlation between clinical symptoms and ToM were retrieved from Pubmed, PsycNet, Embase, Cochrane Library, Science Direct, Proquest, WorldCat, and Open Gray. Correlations for each dimension and each symptom were entered into a random-effect model using a Fisher's r-to-z transformation and were compared using focused-tests. Publication bias was assessed with the Rosenthal failsafe and by inspecting the funnel plot and the standardized residual histogram. The Cognitive/Disorganization (Zr = 0.28) and Negative (Zr = 0.24) dimensions revealed a small to moderate association with ToM, which was significantly stronger than the other dimensions. Within the Cognitive/Disorganization dimension, Difficulty in abstract thinking (Zr = 0.36) and Conceptual disorganization (Zr = 0.39) showed the strongest associations with ToM. The association with the Positive dimension (Zr = 0.16) was small and significantly stronger than the relationship with Depression/Anxiety (Zr = 0.09). Stronger associations were observed between ToM and clinical symptoms in younger patients, those with an earlier age at onset of illness and for tasks assessing a combination of different mental states. The relationships between Cognitive/Disorganization, Negative symptoms, and ToM should be considered in treating individuals with SSD.
Sections du résumé
BACKGROUND AND HYPOTHESIS
Previous studies have suggested links between clinical symptoms and theory of mind (ToM) impairments in schizophrenia spectrum disorders (SSD), but it remains unclear whether some symptoms are more strongly linked to ToM than others.
STUDY DESIGN
A meta-analysis (Prospero; CRD42021259723) was conducted to quantify and compare the strength of the associations between ToM and the clinical symptoms of SSD (Positive, Negative, Cognitive/Disorganization, Depression/Anxiety, Excitability/Hostility). Studies (N = 130, 137 samples) including people with SSD and reporting a correlation between clinical symptoms and ToM were retrieved from Pubmed, PsycNet, Embase, Cochrane Library, Science Direct, Proquest, WorldCat, and Open Gray. Correlations for each dimension and each symptom were entered into a random-effect model using a Fisher's r-to-z transformation and were compared using focused-tests. Publication bias was assessed with the Rosenthal failsafe and by inspecting the funnel plot and the standardized residual histogram.
STUDY RESULTS
The Cognitive/Disorganization (Zr = 0.28) and Negative (Zr = 0.24) dimensions revealed a small to moderate association with ToM, which was significantly stronger than the other dimensions. Within the Cognitive/Disorganization dimension, Difficulty in abstract thinking (Zr = 0.36) and Conceptual disorganization (Zr = 0.39) showed the strongest associations with ToM. The association with the Positive dimension (Zr = 0.16) was small and significantly stronger than the relationship with Depression/Anxiety (Zr = 0.09). Stronger associations were observed between ToM and clinical symptoms in younger patients, those with an earlier age at onset of illness and for tasks assessing a combination of different mental states.
CONCLUSIONS
The relationships between Cognitive/Disorganization, Negative symptoms, and ToM should be considered in treating individuals with SSD.
Identifiants
pubmed: 36244001
pii: 6761756
doi: 10.1093/schbul/sbac150
pmc: PMC10016420
doi:
Types de publication
Meta-Analysis
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
255-274Subventions
Organisme : CIHR
ID : 171198
Pays : Canada
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Références
Schizophr Res. 2010 Jun;119(1-3):115-23
pubmed: 20060686
J Clin Psychiatry. 2014;75 Suppl 2:14-9
pubmed: 24919166
Schizophr Res. 2014 Mar;153(1-3):9-17
pubmed: 24480016
J Nerv Ment Dis. 2016 Mar;204(3):240-3
pubmed: 26919303
Psychiatry Res. 2007 Jan 15;149(1-3):11-23
pubmed: 17107716
Schizophr Res. 2007 Sep;95(1-3):124-33
pubmed: 17630261
Psychiatr Q. 2021 Sep;92(3):947-959
pubmed: 33404993
Early Interv Psychiatry. 2021 Jun;15(3):705-715
pubmed: 32573985
Schizophr Res Cogn. 2021 Sep 29;27:100217
pubmed: 34631435
Compr Psychiatry. 2014 Jan;55(1):25-32
pubmed: 24210952
Schizophr Bull. 2010 Mar;36(2):321-30
pubmed: 18622010
Psychiatry Res Neuroimaging. 2018 Jan 30;271:91-99
pubmed: 29146299
Psychol Med. 2004 Apr;34(3):385-9
pubmed: 15259823
Psychiatry Res. 2009 Jan 30;165(1-2):19-26
pubmed: 19073346
Psychiatry Res. 2012 Dec 30;200(2-3):184-92
pubmed: 22766013
Schizophr Res. 2010 Sep;122(1-3):164-71
pubmed: 20400268
Schizophr Res. 2004 Jul 1;69(1):29-33
pubmed: 15145468
Psychiatr Rehabil J. 2020 Dec;43(4):299-307
pubmed: 32378928
Cogn Neuropsychiatry. 2005 Mar;10(2):87-104
pubmed: 16571454
Neuropsychiatr Dis Treat. 2017 Mar 27;13:937-945
pubmed: 28392697
Acta Psychiatr Scand. 2015 Jun;131(6):472-82
pubmed: 25645449
Issues Ment Health Nurs. 2018 Mar;39(3):269-274
pubmed: 29193986
Psychiatr Danub. 2017 Sep;29(Suppl 3):285-288
pubmed: 28953779
J Forensic Sci. 2009 Mar;54(2):469-73
pubmed: 19187455
Soc Cogn Affect Neurosci. 2006 Sep;1(2):107-21
pubmed: 18985123
Cogn Neuropsychiatry. 1997 Aug;2(3):167-93
pubmed: 25419601
Acta Psychiatr Scand. 2011 Sep;124(3):193-7
pubmed: 21426312
Schizophr Res. 2018 Mar;193:51-57
pubmed: 28648914
Psychiatry Investig. 2020 Dec;17(12):1200-1206
pubmed: 33301666
Schizophr Res. 2006 Jan 1;81(1):101-11
pubmed: 16310343
Schizophr Res. 2007 Feb;90(1-3):316-24
pubmed: 17141477
Psychiatry Res. 2018 Dec;270:293-297
pubmed: 30286366
Schizophr Res. 2019 Aug;210:94-100
pubmed: 31178362
Schizophr Res. 2019 Apr;206:183-193
pubmed: 30527930
Acta Neuropsychiatr. 2016 Aug;28(4):232-8
pubmed: 26916502
Psychol Med. 2007 Apr;37(4):595-601
pubmed: 17094815
Psychol Med. 2009 Apr;39(4):635-43
pubmed: 18606048
Psychol Med. 2009 Apr;39(4):645-54
pubmed: 18694537
Cogn Neuropsychiatry. 2020 Jan;25(1):14-27
pubmed: 31621495
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Psychiatry Clin Neurosci. 2007 Apr;61(2):149-58
pubmed: 17362432
Schizophr Res. 2004 Jul 1;69(1):45-53
pubmed: 15145470
Schizophr Res. 2018 Nov;201:130-136
pubmed: 29751984
Schizophr Bull. 2020 Feb 26;46(2):236-241
pubmed: 31598707
Schizophr Bull. 2012 Jun;38(4):854-64
pubmed: 21345917
Indian J Psychiatry. 2020 Sep-Oct;62(5):544-554
pubmed: 33678836
Schizophr Res. 2015 Feb;161(2-3):407-13
pubmed: 25499044
Psychiatry Res. 2009 May 15;167(1-2):28-35
pubmed: 19346006
Schizophr Res Cogn. 2018 Nov 08;15:21-29
pubmed: 30534527
J Clin Exp Neuropsychol. 2011 Apr;33(4):456-70
pubmed: 21271425
Asia Pac Psychiatry. 2013 Sep;5(3):157-63
pubmed: 23857818
Neuropsychology. 2005 Jul;19(4):494-500
pubmed: 16060824
J Psychiatr Res. 2005 Sep;39(5):499-508
pubmed: 15992559
Psychiatry Res. 2016 Mar 30;237:188-95
pubmed: 26833279
Asian J Psychiatr. 2021 Aug;62:102732
pubmed: 34118560
Psychother Res. 2014;24(2):171-83
pubmed: 24219351
Psychol Med. 2020 Nov;50(15):2557-2565
pubmed: 31576783
Schizophr Res. 2014 Jan;152(1):217-22
pubmed: 24321712
Ment Illn. 2017 Mar 22;9(1):7054
pubmed: 28479973
Schizophr Res. 2017 Jul;185:161-166
pubmed: 28089135
Clin Psychol Rev. 2012 Dec;32(8):724-40
pubmed: 23059624
Psychiatry Res. 2014 May 30;216(3):325-32
pubmed: 24636245
Schizophr Res. 2017 Jun;184:96-102
pubmed: 27979698
Acta Psychiatr Scand. 2009 Mar;119(3):199-208
pubmed: 19016669
Schizophr Res. 2014 Nov;159(2-3):499-505
pubmed: 25305062
Psychiatry Res. 2018 Nov;269:56-63
pubmed: 30145302
Scand J Psychol. 2019 Aug;60(4):295-303
pubmed: 31111499
Schizophr Res. 2016 Jul;174(1-3):192-196
pubmed: 27197903
Klinik Psikofarmakol Bulteni. 2010;20(1):5-13
pubmed: 25584026
Eur Arch Psychiatry Clin Neurosci. 2007 Feb;257(1):12-22
pubmed: 17036260
J Nerv Ment Dis. 2004 Jan;192(1):12-8
pubmed: 14718771
Eur Psychiatry. 2021 Feb 18;64(1):e23
pubmed: 33597064
Brain Lang. 2013 Sep;126(3):231-42
pubmed: 23867921
Schizophr Bull. 2006 Apr;32(2):214-9
pubmed: 16481659
Psychopathology. 2002 Sep-Oct;35(5):280-8
pubmed: 12457019
Schizophr Res. 2011 Feb;125(2-3):152-60
pubmed: 20965699
BMC Psychiatry. 2020 Feb 10;20(1):59
pubmed: 32041577
Psychiatry Res. 2005 Feb 28;133(2-3):135-47
pubmed: 15740990
Psychiatry Res. 2015 Jan 30;225(1-2):169-174
pubmed: 25467703
Br J Psychiatry. 2007 Jul;191:5-13
pubmed: 17602119
Schizophr Bull. 2017 Oct 21;43(6):1229-1239
pubmed: 28199713
Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):673-82
pubmed: 24126470
J Psychiatr Res. 2020 Oct;129:206-213
pubmed: 32781338
Riv Psichiatr. 2016 Jan-Feb;51(1):20-9
pubmed: 27030346
Annu Rev Psychol. 2001;52:59-82
pubmed: 11148299
Br J Clin Psychol. 2021 Sep;60(3):339-356
pubmed: 34036577
BMC Psychiatry. 2014 Dec 04;14:316
pubmed: 25472859
Schizophr Res. 2020 Feb;216:118-128
pubmed: 31899095
Early Interv Psychiatry. 2021 Aug;15(4):993-1001
pubmed: 33037774
Cogn Neuropsychiatry. 2005 Aug;10(4):249-86
pubmed: 16571462
Schizophr Res. 2014 Mar;153(1-3):54-9
pubmed: 24503175
Psychiatry Res. 2017 Oct;256:342-344
pubmed: 28675859
J Psychiatr Res. 2021 Nov;143:429-435
pubmed: 34656875
Schizophr Res. 2017 Dec;190:150-159
pubmed: 28285028
Front Psychiatry. 2018 Jan 10;8:302
pubmed: 29375405
Front Psychiatry. 2021 Apr 09;12:607154
pubmed: 33897481
Psychiatry Res. 2019 Feb;272:737-743
pubmed: 30832194
Neurosci Biobehav Rev. 2019 Oct;105:212-219
pubmed: 31415864
J Formos Med Assoc. 2020 Jan;119(1 Pt 3):439-448
pubmed: 31558338
Compr Psychiatry. 2016 Nov;71:106-120
pubmed: 27653782
Int J Psychiatry Clin Pract. 2021 Sep;25(3):252-257
pubmed: 32862741
Psychiatry Res. 2015 Feb 28;225(3):374-80
pubmed: 25563671
Cortex. 2019 Sep;118:4-18
pubmed: 29903609
Schizophr Bull. 2011 Sep;37 Suppl 2:S23-32
pubmed: 21860044
Schizophr Bull. 2020 Feb 26;46(2):225-226
pubmed: 31776580
Dev Sci. 2010 Mar;13(2):331-8
pubmed: 20136929
Neurosci Biobehav Rev. 2011 Jan;35(3):573-88
pubmed: 20620163
J Psychiatr Res. 2015 Sep;68:254-60
pubmed: 26228427
Cogn Neuropsychiatry. 2019 Nov;24(6):454-469
pubmed: 31578118
Schizophr Res. 2018 Nov;201:187-195
pubmed: 29958750
J Anxiety Disord. 2014 Mar;28(2):169-77
pubmed: 24239443
Schizophr Res. 2010 Sep;122(1-3):156-63
pubmed: 20051314
Compr Psychiatry. 2014 Feb;55(2):349-56
pubmed: 24262115
BMC Psychiatry. 2005 Feb 24;5:12
pubmed: 15730565
J Nerv Ment Dis. 2010 Jul;198(7):516-9
pubmed: 20611056
Psychiatry Res. 2011 Apr 30;186(2-3):203-9
pubmed: 20947175
Eur Arch Psychiatry Clin Neurosci. 2007 Sep;257(6):337-9
pubmed: 17464545
Psychiatry Res. 2013 Jan 30;205(1-2):25-9
pubmed: 23017655
Psychiatry Res. 2015 Jan 30;225(1-2):197-201
pubmed: 25482394
Schizophr Bull. 2021 Apr 29;47(3):695-711
pubmed: 33433606
Front Psychiatry. 2013 May 06;4:30
pubmed: 23653606
Front Psychol. 2016 May 04;7:592
pubmed: 27199826
Psychiatry Res. 2014 Dec 15;220(1-2):112-7
pubmed: 25130778
Psychiatry Res. 2006 Dec 7;145(2-3):95-103
pubmed: 17074402
Schizophr Res. 2018 Jul;197:349-356
pubmed: 29122405
Psychol Med. 2021 Dec;51(16):2846-2855
pubmed: 32466811
Psychiatry Res. 2018 Jan;259:463-469
pubmed: 29145104
Psychiatry Res. 2011 Nov 30;190(1):9-17
pubmed: 20417974
Psychiatry Res. 2007 Aug 30;152(2-3):121-8
pubmed: 17507100
Schizophr Res. 2001 Mar 1;47(2-3):299-308
pubmed: 11278148
Br J Clin Psychol. 2013 Jun;52(2):115-28
pubmed: 24215143
Schizophr Res. 2016 Mar;171(1-3):176-81
pubmed: 26785807
Riv Psichiatr. 2012 Jul-Aug;47(4):327-36
pubmed: 23023084
Psychiatry Res. 2013 Sep 30;209(2):129-35
pubmed: 23375626
Psychol Med. 2008 Nov;38(11):1577-83
pubmed: 18005499
Res Synth Methods. 2017 Dec;8(4):537-553
pubmed: 28801932
Psychol Med. 2015 Jul;45(10):2031-43
pubmed: 25647289
Psychiatriki. 2019 Jan-Mar;30(1):17-23
pubmed: 31115350
BMC Psychiatry. 2013 May 17;13:141
pubmed: 23683146
Behav Res Ther. 2006 May;44(5):699-713
pubmed: 16038873
J Affect Disord. 2021 Mar 1;282:329-339
pubmed: 33421860
Cogn Neuropsychiatry. 2011 Jan;16(1):71-91
pubmed: 20803360
Cogn Neuropsychiatry. 2012;17(1):64-89
pubmed: 22216944
Cogn Neuropsychiatry. 2006 Jul;11(4):416-36
pubmed: 17354079
Schizophr Bull. 2014 Jul;40(4):813-23
pubmed: 23728248
Schizophr Res. 2007 May;92(1-3):151-9
pubmed: 17346931
Schizophr Res. 2017 Jun;184:52-58
pubmed: 27913157
Noro Psikiyatr Ars. 2017 Jun;54(2):162-167
pubmed: 28680315
Schizophr Res Cogn. 2017 Sep 26;10:15-19
pubmed: 29114452
Schizophr Bull. 2019 Apr 25;45(3):629-638
pubmed: 30107517
BMC Psychiatry. 2014 May 13;14:138
pubmed: 24885177
Schizophr Bull. 2013 Sep;39(5):979-92
pubmed: 22949733
Neuropsychology. 2017 Feb;31(2):209-219
pubmed: 27808537
Cogn Neuropsychiatry. 2020 Jul;25(4):269-280
pubmed: 32522078
Schizophr Res. 2015 Aug;166(1-3):1-8
pubmed: 26049215
BMC Psychiatry. 2020 Sep 29;20(1):470
pubmed: 32993582
Schizophr Res. 2015 Mar;162(1-3):42-6
pubmed: 25623602
Psychol Med. 2002 Oct;32(7):1273-84
pubmed: 12420896
Front Psychiatry. 2020 Dec 04;11:603933
pubmed: 33343430
Psychol Assess. 2013 Mar;25(1):117-26
pubmed: 22731676
Schizophr Res. 2013 Mar;144(1-3):31-6
pubmed: 23347949
J Psychiatr Res. 2020 Aug;127:35-41
pubmed: 32460156
Behav Brain Funct. 2009 Jan 23;5:6
pubmed: 19166576
Schizophr Bull. 2013 Jan;39(1):186-96
pubmed: 21976710