Chemogenetic stimulation of adult neurogenesis, and not neonatal neurogenesis, is sufficient to improve long-term memory accuracy.
Adult neurogenesis
Chemogenetic
Hippocampus
Memory
Journal
Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
19
04
2022
revised:
21
09
2022
accepted:
06
10
2022
pubmed:
17
10
2022
medline:
7
12
2022
entrez:
16
10
2022
Statut:
ppublish
Résumé
Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of adult neurogenesis is a sufficient condition to improve memory performance remains unclear. Here, we developed and validated, using ex-vivo electrophysiology, a chemogenetic approach that combines selective tagging and activation of discrete adult-born neuron populations. Then we demonstrated that, in rats, this activation can improve accuracy and strength of remote memory. These results show that stimulation of adult-born neuron activity can counteract the natural fading of memory traces that occurs with the passage of time. This opens up new avenues for treating memory problems that may arise over time.
Identifiants
pubmed: 36244613
pii: S0301-0082(22)00150-2
doi: 10.1016/j.pneurobio.2022.102364
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102364Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing interests.