Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque.
Journal
Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
18
10
2022
Statut:
ppublish
Résumé
Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC phenotype can modulate coronary artery disease (CAD) risk. Allelic variation at 15q22.33 has been identified by genome-wide association studies to modify the risk of CAD and is associated with the expression of
Identifiants
pubmed: 36246779
doi: 10.1038/s44161-022-00042-8
pmc: PMC9560061
mid: NIHMS1785285
doi:
Types de publication
Journal Article
Langues
eng
Pagination
322-333Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL143847
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL153798
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134817
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151535
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors have no competing interests to declare.
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