Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population.
AMD, age-related macular degeneration
CFP, color fundus photograph
CI, confidence interval
Drusen subtypes
GA, geographic atrophy
Longitudinal changes
OCT, optical coherene tomography
Pachydrusen
Population-based cohort study
RPE, retinal pigment epithelium
Journal
Ophthalmology science
ISSN: 2666-9145
Titre abrégé: Ophthalmol Sci
Pays: Netherlands
ID NLM: 9918230896206676
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
13
05
2021
revised:
27
10
2021
accepted:
28
10
2021
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Longitudinal population-based cohort study conducted from 2013 through 2017. Residents 40 years of age or older. Nonmydriatic color fundus photographs were used to grade drusen subtypes and retinal pigment epithelium (RPE) abnormalities according to the Three Continent Age-Related Macular Degeneration Consortium. The 5-year changes of each drusen were investigated. The prevalence of each drusen subtype and the 5-year changes of each drusen. Among 1731 participants, 1660 participants had gradable photographs that were assessed. The age-adjusted prevalence of soft drusen, pachydrusen, and pseudodrusen was 4.3% (95% confidence interval [CI], 3.2%-5.8%), 7.7% (95% CI, 6.2%-9.7%), and 2.8% (95% CI, 1.7%-4.2%), respectively. Pachydrusen accounted for 82.0% (n = 50) of the extramacular drusen (n = 61). Pigment abnormalities were seen in 28.3% and 8.3% of eyes with soft drusen and pachydrusen, respectively ( The prevalence of pachydrusen was higher than that of soft drusen and pseudodrusen combined. Pachydrusen may regress over time and typically is not associated with RPE atrophy as detected using color fundus photographs.
Identifiants
pubmed: 36246945
doi: 10.1016/j.xops.2021.100081
pii: S2666-9145(21)00083-X
pmc: PMC9560559
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100081Informations de copyright
© 2021 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology.
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