Increased T- and B-cells associated with the phenotype of autoimmune limbic encephalitis with mainly memory dysfunction.
Autoantibodies
Autoimmune encephalitis
Immune cells
Neuropsychology
Phenotype
Verbal memory
Journal
Journal of translational autoimmunity
ISSN: 2589-9090
Titre abrégé: J Transl Autoimmun
Pays: Netherlands
ID NLM: 101759413
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
08
2022
revised:
24
09
2022
accepted:
25
09
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Our goal is to investigate the autoantibodies' presence and immune cells in the bioprobes of autoimmune encephalitis (AE) patients with distinct phenotypes as a promising target in AE. We retrospectively analyzed immune cells via flow cytometry, serum and cerebrospinal fluid (CSF) autoantibodies, electroencephalography, magnetic resonance imaging in 94 AE patients with suspected temporal lobe epilepsy and classified neuropsychological phenotypes according to their occurrence. We detected different phenotypes in 94 AE patients [10.6% with isolated memory dysfunction (MEM), 11.7% with mood-dysfunction, 12.7% with mood and memory dysfunction, 13.8% with memory and attention dysfunction, 18.1% with memory, mood and attention disturbances and 20.2% with no mood, memory or attention dysfunction]. We did discern a relevant association of phenotypes and CSF antibody-positivity on CSF CD4 Taken together, the phenotypes in combination with CSF antibody-positivity are biomarkers for stratifying patients. Furthermore, our results confirm the role of CD4
Sections du résumé
Background
UNASSIGNED
Our goal is to investigate the autoantibodies' presence and immune cells in the bioprobes of autoimmune encephalitis (AE) patients with distinct phenotypes as a promising target in AE.
Methods
UNASSIGNED
We retrospectively analyzed immune cells via flow cytometry, serum and cerebrospinal fluid (CSF) autoantibodies, electroencephalography, magnetic resonance imaging in 94 AE patients with suspected temporal lobe epilepsy and classified neuropsychological phenotypes according to their occurrence.
Results
UNASSIGNED
We detected different phenotypes in 94 AE patients [10.6% with isolated memory dysfunction (MEM), 11.7% with mood-dysfunction, 12.7% with mood and memory dysfunction, 13.8% with memory and attention dysfunction, 18.1% with memory, mood and attention disturbances and 20.2% with no mood, memory or attention dysfunction]. We did discern a relevant association of phenotypes and CSF antibody-positivity on CSF CD4
Discussion
UNASSIGNED
Taken together, the phenotypes in combination with CSF antibody-positivity are biomarkers for stratifying patients. Furthermore, our results confirm the role of CD4
Identifiants
pubmed: 36247087
doi: 10.1016/j.jtauto.2022.100167
pii: S2589-9090(22)00028-4
pmc: PMC9563330
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100167Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Sleep. 2019 Feb 1;42(2):
pubmed: 30445542
Brain. 2022 Jun 3;145(5):1711-1725
pubmed: 35661859
JAMA Neurol. 2017 Jan 01;74(1):50-59
pubmed: 27893017
Brain Struct Funct. 2019 May;224(4):1599-1607
pubmed: 30863886
Neurol Neuroimmunol Neuroinflamm. 2016 Apr 29;3(3):e232
pubmed: 27213174
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21546-21556
pubmed: 32817525
Lancet Neurol. 2016 Apr;15(4):391-404
pubmed: 26906964
Neurobiol Aging. 2015 Jan;36(1):81-9
pubmed: 25277040
J Neural Transm (Vienna). 2015 Mar;122(3):357-62
pubmed: 24990310
J Neuroimmunol. 2013 Dec 15;265(1-2):128-30
pubmed: 24183642
Hippocampus. 2014 Apr;24(4):446-54
pubmed: 24375772
Front Hum Neurosci. 2019 Feb 05;13:23
pubmed: 30804768
Epilepsy Behav. 2020 Jan;102:106682
pubmed: 31846897
Curr Top Behav Neurosci. 2020;44:85-123
pubmed: 31292938
Brain. 2015 Jan;138(Pt 1):94-109
pubmed: 25392198
Brain. 2016 Oct;139(Pt 10):2641-2652
pubmed: 27543972
Epilepsy Behav. 2020 May;106:107016
pubmed: 32199348
Eur J Neurol. 2019 Jun;26(6):919-926
pubmed: 30659722
Brain Sci. 2022 Apr 03;12(4):
pubmed: 35448006
Handb Clin Neurol. 2016;133:185-97
pubmed: 27112678
Lancet Psychiatry. 2019 Mar;6(3):235-246
pubmed: 30765329
J Neurol. 2021 Feb;268(2):455-466
pubmed: 32816110
Neuroscience. 2019 Feb 21;400:120-131
pubmed: 30625332
Ann Neurol. 2021 Apr;89(4):666-685
pubmed: 33368582
Clin Chim Acta. 1987 Mar 30;163(3):319-28
pubmed: 3581475
Brain Sci. 2021 Apr 29;11(5):
pubmed: 33947002
J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1191-1199
pubmed: 29886429
Brain. 2018 Feb 1;141(2):348-356
pubmed: 29272336
Neuron. 2018 Oct 10;100(1):91-105.e9
pubmed: 30146304
Neuroscience. 2015 Nov 19;309:68-83
pubmed: 26012492
Epilepsy Behav. 2018 Feb;79:93-99
pubmed: 29253681
Ann Clin Transl Neurol. 2021 Dec;8(12):2289-2301
pubmed: 34841709