Healthy Ageing Reflected in Innate and Adaptive Immune Parameters.
age-related
lymphocyte immunophenotyping
neutrophils
oxidative activity
Journal
Clinical interventions in aging
ISSN: 1178-1998
Titre abrégé: Clin Interv Aging
Pays: New Zealand
ID NLM: 101273480
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
05
2022
accepted:
06
09
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
19
10
2022
Statut:
epublish
Résumé
The aim of the paper is to establish and quantify the relation between healthy ageing and the innate and adaptive immune parameters as indicators of age-related diseases. In order to observe the immunological changes that occur according to age, several humoral and cellular immune parameters were investigated for 288 healthy donors (30-80 years). Subjects' selection was done using clinical, biochemical and immunological parameters of inclusion/exclusion criteria from SENIEUR protocol. Age-related changes were observed for both humoral and cellular immune parameters. Lymphocyte immunophenotyping revealed several significant differences in the distribution of cells, both intra- and inter-age groups, namely decreased values of T-CD3 Overall healthy ageing is governed by some immune-related deregulations that account for immune exhaustion due to numerous developed immune processes during a life-time and the age-related diseases.
Identifiants
pubmed: 36247200
doi: 10.2147/CIA.S375926
pii: 375926
pmc: PMC9555218
doi:
Substances chimiques
Acetates
0
Myristates
0
N-Formylmethionine Leucyl-Phenylalanine
59880-97-6
Tetradecanoylphorbol Acetate
NI40JAQ945
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1513-1526Informations de copyright
© 2022 Munteanu et al.
Déclaration de conflit d'intérêts
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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