Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial.
biomarkers
computerized cognitive training
mindfulness
neuroimaging
physical exercise
stroke
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
05
2022
accepted:
31
08
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT ( The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes. www.ClinicalTrials.gov, identifier NCT04759950.
Sections du résumé
Background
UNASSIGNED
Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health.
Materials and methods
UNASSIGNED
One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (
Results
UNASSIGNED
The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample.
Discussion
UNASSIGNED
The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes.
Clinical trial registration
UNASSIGNED
www.ClinicalTrials.gov, identifier NCT04759950.
Identifiants
pubmed: 36248000
doi: 10.3389/fnagi.2022.936077
pmc: PMC9557300
doi:
Banques de données
ClinicalTrials.gov
['NCT04759950']
Types de publication
Journal Article
Langues
eng
Pagination
936077Informations de copyright
Copyright © 2022 Bermudo-Gallaguet, Ariza, Dacosta-Aguayo, Agudelo, Camins-Vila, Boldó, Carrera, Vidal, Ferrer-Uris, Busquets, Via, Pera, Cáceres, Gomis, García-Molina, Tormos, Arrabé, Diez, Durà Mata, Torán-Monserrat, Soriano-Raya, Domènech, Perera-Lluna, Erickson and Mataró.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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