Update in Cushing disease: What the neurosurgeon has to KNOW, on behalf of the EANS skull base section.
ACTH
Cushing disease
Hypercortisolism
Pituitary adenoma
Transsphenoidal adenomectomy
Journal
Brain & spine
ISSN: 2772-5294
Titre abrégé: Brain Spine
Pays: Netherlands
ID NLM: 9918470888906676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
06
2022
revised:
27
06
2022
accepted:
19
07
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Cushing's disease is a state of chronic and excessive cortisol levels caused by a pituitary adenoma. CD is a complex entity and often entails difficulties in its diagnosis and management. For that reason, there are still controversial points to that respect. The aim of this consensus paper of the skull base section of the EANS is to review the main aspects of the disease a neurosurgeon has to know and also to offer updated recommendations on the controversial aspects of its management. PUBMED database was used to search the most pertinent articles published on the last 5 years related with the management of CD. A summary of literature evidence was proposed for discussion within the EANS skull base section and other international experts. This article represents the consensual opinion of the task force regarding optimal management and surgical strategy in CD. After discussion in the group several recommendations and suggestions were elaborated. Patients should be treated by an experienced multidisciplinary team. Accurate clinical, biochemical and radiological diagnosis is mandatory. The goal of treatment is the complete adenoma resection to achieve permanent remission. If this is not possible, the treatment aims to achieving eucortisolism. Radiation therapy is recommended to patients with CD when surgical options have been exhausted. All patients in remission should be tested all life-long.
Identifiants
pubmed: 36248125
doi: 10.1016/j.bas.2022.100917
pii: S2772-5294(22)00058-3
pmc: PMC9560580
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100917Informations de copyright
© 2022 The Authors. Published by Elsevier B.V. on behalf of EUROSPINE, the Spine Society of Europe, EANS, the European Association of Neurosurgical Societies.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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