Assessment of plasma Catestatin in COVID-19 reveals a hitherto unknown inflammatory activity with impact on morbidity-mortality.
COVID
Catestatin
Chromogranin A
Innate immunity
critically ill
hypoxia
nosocomial disease
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
07
2022
accepted:
07
09
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
19
10
2022
Statut:
epublish
Résumé
Neuroendocrine cells release Catestatin (CST) from Chromogranin A (CgA) to regulate stress responses. As regards COVID-19 patients (COVID+) requiring oxygen supply, to date nobody has studied CST as a potential mediator in the regulation of immunity. Admission plasma CST and CgA - its precursor - concentrations were measured (ELISA test) in 73 COVID+ and 27 controls. Relationships with demographics, comorbidities, disease severity and outcomes were analysed (Mann-Whitney, Spearman correlation tests, ROC curves). Among COVID+, 49 required ICU-admission (COVID+ICU+) and 24 standard hospitalization (COVID+ICU-). Controls were either healthy staff (COVID-ICU-, n=11) or COVID-ICU+ patients (n=16). Median plasma CST were higher in COVID+ than in controls (1.6 [1.02; 3.79] Respiratory COVID patients release significant amounts of CST in the plasma making this protein widely available for the neural regulation of immunity. If confirmed prospectively, plasma CST will reliably help in predicting in-hospital mortality, whereas CgA will facilitate the detection of patients prone to care-related infections.
Identifiants
pubmed: 36248786
doi: 10.3389/fimmu.2022.985472
pmc: PMC9559198
doi:
Substances chimiques
Chromogranin A
0
Peptide Fragments
0
chromogranin A (344-364)
0
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
985472Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Schneider, Le Borgne, Herbrecht, Danion, Solis, Hellé, Betscha, Clere-Jehl, Lefebvre, Castelain, Goumon and Metz-Boutigue.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur Radiol. 2020 Aug;30(8):4356-4357
pubmed: 32193637
Lancet. 2021 Aug 14;398(10300):622-637
pubmed: 34217425
Nat Neurosci. 2017 Feb;20(2):156-166
pubmed: 28092663
Immunology. 2011 Apr;132(4):527-39
pubmed: 21214543
Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):383-91
pubmed: 23755753
Intensive Care Med. 2022 Jul;48(7):876-887
pubmed: 35676335
Endocrinology. 2008 Feb;149(2):749-57
pubmed: 17991725
Endocrinology. 2009 Aug;150(8):3547-57
pubmed: 19372204
Front Cell Infect Microbiol. 2021 Oct 21;11:751232
pubmed: 34746027
J Biol Chem. 2003 Aug 22;278(34):32058-67
pubmed: 12799369
Clin Chem Lab Med. 2020 Jun 25;58(7):1021-1028
pubmed: 32286245
Pediatr Diabetes. 2019 Aug;20(5):549-555
pubmed: 30714297
Am J Hum Genet. 2004 Feb;74(2):197-207
pubmed: 14740315
Mol Endocrinol. 2000 Oct;14(10):1525-35
pubmed: 11043569
PLoS One. 2022 Apr 25;17(4):e0267235
pubmed: 35468164
Circ Res. 1991 Aug;69(2):466-74
pubmed: 1860185
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Shock. 2018 May;49(5):522-528
pubmed: 29049134
Diabetes. 2018 May;67(5):841-848
pubmed: 29432123
Regul Pept. 2000 Nov 24;95(1-3):9-17
pubmed: 11062327
Trends Neurosci. 2019 Aug;42(8):537-551
pubmed: 31213389
Thromb Haemost. 2018 Jan;118(1):182-194
pubmed: 29304538
J Clin Invest. 1997 Sep 15;100(6):1623-33
pubmed: 9294131
Clin Chem. 2008 Sep;54(9):1497-503
pubmed: 18635750
Biochim Biophys Acta. 1998 Aug 21;1376(2):173-220
pubmed: 9748559
PLoS One. 2022 Jan 26;17(1):e0261679
pubmed: 35081105
J Biol Chem. 1999 Jan 29;274(5):2920-8
pubmed: 9915830
Hypertension. 2016 Aug;68(2):334-47
pubmed: 27324226
Regul Pept. 2010 Jun 8;162(1-3):33-43
pubmed: 20116404
J Biol Chem. 2012 Dec 21;287(52):43840-52
pubmed: 23105094
Aging Clin Exp Res. 2021 Oct;33(10):2887-2898
pubmed: 34328636
Cell Mol Life Sci. 2005 Feb;62(3):377-85
pubmed: 15723172
Cell. 2020 Sep 17;182(6):1401-1418.e18
pubmed: 32810439
Blood. 2013 Jan 10;121(2):392-402
pubmed: 23190532
JAMA. 1993 Dec 22-29;270(24):2957-63
pubmed: 8254858
Biomed Pharmacother. 2021 Feb;134:111113
pubmed: 33341043
Front Immunol. 2018 Oct 04;9:2199
pubmed: 30337922
Neurosci Lett. 2019 Oct 15;711:134434
pubmed: 31421156
PLoS One. 2020 Nov 17;15(11):e0241955
pubmed: 33201896
Int J Mol Sci. 2022 Feb 13;23(4):
pubmed: 35216181
Sci Rep. 2021 Aug 2;11(1):15615
pubmed: 34341386
J Clin Invest. 2000 Oct;106(7):907-15
pubmed: 11018079
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
PLoS One. 2009;4(2):e4501
pubmed: 19225567
Biochemistry. 2003 Jun 17;42(23):6938-46
pubmed: 12795588
J Cell Sci. 2012 May 1;125(Pt 9):2323-37
pubmed: 22357947
J Infect Dis. 2021 Apr 23;223(8):1322-1333
pubmed: 33524124