Zebrafish Avatars of rectal cancer patients validate the radiosensitive effect of metformin.
metformin
neoadjuvant chemoradiation
radiotherapy
rectal cancer
zebrafish Avatars
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
01
2022
accepted:
23
08
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Neoadjuvant chemoradiation (nCRT) followed by surgery represents the standard of care in patients with locally advanced rectal cancer. Increasing radiotherapy (RT) doses and chemotherapy cycles with 5FU have been associated with increased rates of complete response, however these strategies imply significant toxicity. In the last years, epidemiologic findings have demonstrated that metformin is associated with significantly higher rates of pathological complete response to nCRT. Also, pre-clinical studies using cell lines provide evidence for the radiosensitive effect of metformin. However, no studies have been performed using rectal cancer patient samples to test this radiosensitive effect of metformin and compared it to the standard 5FU. Here, we designed an experimental study to compare both radiosensitizers in the zebrafish xenograft model (zAvatar), using rectal cancer surgical specimens and diagnostic biopsies. Patient zAvatars confirmed that metformin has indeed a powerful
Identifiants
pubmed: 36249066
doi: 10.3389/fonc.2022.862889
pmc: PMC9554544
doi:
Types de publication
Journal Article
Langues
eng
Pagination
862889Informations de copyright
Copyright © 2022 Costa, Fernandez, Parés, Rio-Tinto, Santiago, Castillo-Martin, Parvaiz and Fior.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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