Generation of a genetically modified pig model with CREBRF
CREBRF
obesity
oxidative stress
pig model
type 2 diabetes
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
13
07
2022
accepted:
03
10
2022
entrez:
17
10
2022
pubmed:
18
10
2022
medline:
20
10
2022
Statut:
ppublish
Résumé
Obesity is among the strongest risk factors for type 2 diabetes (T2D). The CREBRF missense allele rs373863828 (p. Arg457Gln, p. R457Q) is associated with increased body mass index but reduced risk of T2D in people of Pacific ancestry. To investigate the functional consequences of the CREBRF variant, we introduced the corresponding human mutation R457Q into the porcine genome. The CREBRF
Identifiants
pubmed: 36250915
doi: 10.1096/fj.202201117
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Malondialdehyde
4Y8F71G49Q
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22611Informations de copyright
© 2022 Federation of American Societies for Experimental Biology.
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