Dimethyl Cardamonin from Fruits of Campomanesia reitziana D. Legrand Promotes Gastroprotection and Gastric Healing Effects in Rodents.
cardamonin
chalcone
fruits
gastric secretion
gastric ulcer
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
02
08
2022
accepted:
17
10
2022
pubmed:
18
10
2022
medline:
28
12
2022
entrez:
17
10
2022
Statut:
ppublish
Résumé
Campomanesia reitziana D. Legrand (Myrtaceae) displays antiulcer properties when given to rodents. The major active chemical components of C. reitziana are chalcones, including 4',6'-dihydroxy-2'-methoxy-3',5'-dimethylchalcone or dimethyl cardamonin (DMC); therefore, we hypothesized that this compound could have antiulcer effects and the present study aimed to evaluate its gastroprotective and gastric healing properties. DMC was isolated from the fruits of C. reitziana, and its gastroprotective effect was evaluated by ethanol and indomethacin-induced gastric ulcer models in mice (0.1 mg/kg, i.p. and 1 and 3 mg/kg, p.o.). Oxidative stress and inflammatory parameters were analyzed in the gastric tissue. Moreover, its gastric healing effect was evaluated in rats. In addition, the compound's mode of action was evaluated in vivo and in vitro by measuring H
Identifiants
pubmed: 36251014
doi: 10.1002/cbdv.202200727
doi:
Substances chimiques
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone
0
Chalcones
0
Plant Extracts
0
Anti-Ulcer Agents
0
Ethanol
3K9958V90M
Adenosine Triphosphatases
EC 3.6.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200727Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Organisme : Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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