Tertiary lymphoid tissues in kidney diseases: a perspective for the pediatric nephrologist.
Chronic kidney disease
IgA nephropathy
Immunosenescence
Kidney transplantation
Lupus nephritis
Tertiary lymphoid tissues
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
01
07
2022
accepted:
20
09
2022
revised:
05
09
2022
medline:
31
3
2023
pubmed:
18
10
2022
entrez:
17
10
2022
Statut:
ppublish
Résumé
Chronic kidney disease (CKD) is a major public health problem worldwide. In the pediatric population, CKD is also an important health issue because it causes several comorbid conditions that can have long-term consequences beyond the pediatric age. Chronic inflammation is a common pathological feature of CKD, irrespective of etiology, and leads to maladaptive repair and kidney dysfunction. Tertiary lymphoid tissues (TLTs) are ectopic lymphoid structures that develop in non-lymphoid organs under chronic inflammation caused by pathological conditions, including infections, autoimmune diseases, and cancers. TLTs in the kidneys have been poorly researched due to the lack of an animal model. We have recently found that, in aged but not young mice, TLTs develop in multiple kidney injury models, and the analysis of age-dependent TLTs has brought about several novel insights into the development and pathogenic impacts of TLTs in the kidney. Age-dependent TLT formation is also observed in human kidneys. In addition to aged kidneys, TLT development is also reported in several human kidney diseases including kidney allografts, lupus nephritis, and IgA nephropathy in both adults and children. In this review, we describe the novel findings on TLTs in the kidney obtained mainly from the analysis of age-dependent TLTs and discuss the clinical relevance of TLTs in kidney diseases.
Identifiants
pubmed: 36251070
doi: 10.1007/s00467-022-05770-4
pii: 10.1007/s00467-022-05770-4
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1399-1409Informations de copyright
© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.
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