Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching.
Purkinje cell
cerebellum
neural activity
reaching
receptive field
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
03
02
2022
accepted:
07
10
2022
pubmed:
19
10
2022
medline:
3
12
2022
entrez:
18
10
2022
Statut:
ppublish
Résumé
The cerebellum is the largest sensorimotor structure in the brain. A fundamental organizational feature of its cortex is its division into a series of rostrocaudally elongated zones. These are defined by their inputs from specific parts of the inferior olive and Purkinje cell output to specific cerebellar and vestibular nuclei. However, little is known about how patterns of neuronal activity in zones, and their microcircuit subdivisions, microzones, are related to behaviour in awake animals. In the present study, we investigated the organization of microzones within the C3 zone and their activity during a skilled forelimb reaching task in cats. Neurons in different microzones of the C3 zone, functionally determined by receptive field characteristics, differed in their patterns of activity during movement. Groups of Purkinje cells belonging to different receptive field classes, and therefore belonging to different microzones, were found to collectively encode different aspects of the reach controlled by the C3 zone. Our results support the hypothesis that the cerebellar C3 zone is organized and operates within a microzonal frame of reference, with a specific relationship between the sensory input to each microzone and its motor output. KEY POINTS: A defining feature of cerebellar organization is its division into a series of zones and smaller subunits termed microzones. Much of how zones and microzones are organized has been determined in anaesthetized preparations, and little is known about their function in awake animals. We recorded from neurons in the forelimb part of the C3 zone 'in action' by recording from single cerebellar cortical neurons located in different microzones defined by their peripheral receptive field properties during a forelimb reach-retrieval task in cats. Neurons from individual microzones had characteristic patterns of activity during movement, indicating that function is organized in relation to microcomplexes.
Identifiants
pubmed: 36254104
doi: 10.1113/JP282928
pmc: PMC10099968
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5077-5099Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : 1503834
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100626
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
Références
Brain Res. 1966 Dec;3(2):204-7
pubmed: 5971524
J Physiol. 1994 Jan 15;474(2):245-60
pubmed: 8006811
J Physiol. 1988 Jul;401:399-415
pubmed: 3171993
PLoS One. 2011 Apr 28;6(4):e18822
pubmed: 21552556
J Neurosci. 2002 Nov 15;22(22):9668-78
pubmed: 12427822
J Neurosci. 2014 Feb 5;34(6):2321-30
pubmed: 24501371
Front Neural Circuits. 2012 Dec 11;6:97
pubmed: 23248585
J Neurosci. 2009 Jan 7;29(1):250-62
pubmed: 19129401
Annu Rev Neurosci. 1992;15:403-42
pubmed: 1575449
J Neurosci. 2013 Jul 10;33(28):11412-24
pubmed: 23843513
J Neurophysiol. 2003 Nov;90(5):3066-86
pubmed: 12904332
Eur J Neurosci. 1996 Dec;8(12):2726-38
pubmed: 8996822
Neurosci Res. 1986 Jul;3(5):457-61
pubmed: 3748475
J Physiol. 1998 Oct 1;512 ( Pt 1):277-93
pubmed: 9729638
J Physiol. 2009 Jan 15;587(2):429-42
pubmed: 19047203
Eur J Neurosci. 2000 Jan;12(1):205-14
pubmed: 10651875
Exp Brain Res. 1992;88(3):615-22
pubmed: 1587319
J Physiol. 1987 Nov;392:315-32
pubmed: 3446782
Exp Brain Res. 1985;57(2):239-55
pubmed: 3972028
Neuron. 2019 Jul 17;103(2):335-348.e5
pubmed: 31174960
Exp Brain Res. 1993;94(2):279-86
pubmed: 8359245
J Neurophysiol. 2011 Nov;106(5):2232-47
pubmed: 21795616
J Physiol. 1997 Jul 1;502 ( Pt 1):203-14
pubmed: 9234207
Anat Embryol (Berl). 1983;167(3):449-62
pubmed: 6625198
J Neurophysiol. 2000 Apr;83(4):1886-99
pubmed: 10758100
J Neurophysiol. 1993 Jan;69(1):74-94
pubmed: 8433135
Cell Rep. 2018 Feb 27;22(9):2322-2333
pubmed: 29490269
J Physiol. 1991 Sep;441:275-84
pubmed: 1816376
J Physiol. 2002 May 1;540(Pt 3):1061-9
pubmed: 11986390
J Physiol. 1979 Apr;289:425-48
pubmed: 458677
J Comp Neurol. 2001 Jan 1;429(1):59-70
pubmed: 11086289
Eur J Neurosci. 2001 Apr;13(7):1303-10
pubmed: 11298790
Elife. 2016 Mar 16;5:
pubmed: 26982219
J Neurosci. 2006 Nov 15;26(46):12067-80
pubmed: 17108180
J Neurophysiol. 1971 Jan;34(1):17-31
pubmed: 5540578
Neural Comput. 2014 Nov;26(11):2379-94
pubmed: 25149694
Nat Rev Neurosci. 2005 Apr;6(4):297-311
pubmed: 15803161
Arch Ital Biol. 2002 Jul;140(3):175-83
pubmed: 12173520
Curr Biol. 2015 May 4;25(9):1157-65
pubmed: 25843032
Commun Biol. 2020 Jul 15;3(1):381
pubmed: 32669638
J Comp Neurol. 1997 Dec 15;389(2):249-63
pubmed: 9416920
Front Syst Neurosci. 2009 Feb 10;3:2
pubmed: 19390639
Nat Rev Neurosci. 2010 Jan;11(1):30-43
pubmed: 19997115
Exp Brain Res. 1980 Jan;38(2):163-72
pubmed: 7358102
J Neurophysiol. 1983 Mar;49(3):745-66
pubmed: 6300353
Eur J Neurosci. 1996 Aug;8(8):1769-79
pubmed: 8921267
Cerebellum. 2003;2(2):101-9
pubmed: 12880177
Brain Res Brain Res Rev. 2002 Oct;40(1-3):152-65
pubmed: 12589914
J Neurosci. 2007 Mar 7;27(10):2493-502
pubmed: 17344387
Exp Brain Res. 1987;66(2):318-38
pubmed: 3595778
J Neurosci. 2011 Oct 12;31(41):14708-20
pubmed: 21994387
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15032-6
pubmed: 9844010
Exp Brain Res. 1981;44(1):71-81
pubmed: 7274364
J Neurophysiol. 1996 Jul;76(1):492-509
pubmed: 8836239
J Neurophysiol. 2000 Oct;84(4):1988-2000
pubmed: 11024092
J Physiol. 1991 Sep;441:257-74
pubmed: 1816375
Neuron. 2002 May 30;34(5):797-806
pubmed: 12062025
Prog Neurobiol. 1993 Jan;40(1):63-87
pubmed: 8424128
Exp Brain Res. 1979 Jul 2;36(2):201-17
pubmed: 488196
Science. 2008 Aug 15;321(5891):977-80
pubmed: 18703744
Q J Exp Psychol A. 1991 Nov;43(4):907-12
pubmed: 1775668
Elife. 2018 Apr 16;7:
pubmed: 29659351
J Neurosci. 2013 Oct 16;33(42):16427-42
pubmed: 24133249
J Comp Neurol. 2009 Jan 10;512(2):282-304
pubmed: 19003905
J Physiol. 1987 Dec;394:351-66
pubmed: 3443969
Nature. 2011 Dec 25;481(7382):502-5
pubmed: 22198670
J Neurocytol. 2004 Jan;33(1):5-21
pubmed: 15173629
J Physiol. 2017 Jan 1;595(1):11-27
pubmed: 27388692
J Physiol. 2006 Mar 15;571(Pt 3):619-37
pubmed: 16423861
Exp Brain Res. 1995;106(3):365-76
pubmed: 8983981
J Neurophysiol. 1989 Jul;62(1):198-211
pubmed: 2754472
Exp Brain Res. 1998 Apr;119(4):493-503
pubmed: 9588784
Exp Brain Res. 1995;102(3):379-92
pubmed: 7737385
Exp Brain Res. 1978 Aug 15;32(4):565-79
pubmed: 689129
J Neurophysiol. 2004 Jan;91(1):576-82
pubmed: 12878717
Elife. 2019 Jan 09;8:
pubmed: 30624204
Brain Res. 2004 Jan 23;996(2):148-58
pubmed: 14697492
J Physiol. 1999 Jul 15;518 ( Pt 2):595-603
pubmed: 10381604