Extrachromosomal circular DNA: Current status and future prospects.
biomedical research
eccDNA
human diseases
medicine
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
18 10 2022
18 10 2022
Historique:
received:
27
06
2022
accepted:
05
10
2022
entrez:
18
10
2022
pubmed:
19
10
2022
medline:
21
10
2022
Statut:
epublish
Résumé
Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans. In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases. Advancements in modern omics technologies have reinvigorated research on eccDNA and shed light on the role of these molecules in a range of diseases and normal cell phenotypes. In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells. We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism. We finally discuss the future prospects of eccDNA, including basic research and clinical application. Thus, with the deepening of understanding and exploration of eccDNAs, they hold great promise in future biomedical research and clinical translational application.
Identifiants
pubmed: 36256570
doi: 10.7554/eLife.81412
pii: 81412
pmc: PMC9578701
doi:
pii:
Substances chimiques
DNA, Circular
0
DNA
9007-49-2
Biomarkers
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Zhao et al.
Déclaration de conflit d'intérêts
YZ, LY, SZ, XS, XZ No competing interests declared
Références
Front Vet Sci. 2021 Sep 09;8:693641
pubmed: 34568472
Cell Death Dis. 2022 Feb 22;13(2):171
pubmed: 35194030
Nucleic Acids Res. 2019 May 21;47(9):4586-4596
pubmed: 30828735
Cancer Cell. 2021 May 10;39(5):694-707.e7
pubmed: 33836152
Cytogenet Genome Res. 2021;161(12):578-584
pubmed: 35021177
Crit Rev Oncol Hematol. 2021 Oct;166:103477
pubmed: 34534658
Genome Biol. 2021 Jun 30;22(1):195
pubmed: 34193237
Nature. 2021 Nov;599(7884):308-314
pubmed: 34671165
Neural Regen Res. 2018 Feb;13(2):173-180
pubmed: 29557356
Nat Rev Cancer. 2019 May;19(5):283-288
pubmed: 30872802
Cell Rep. 2015 Jun 23;11(11):1749-59
pubmed: 26051933
PLoS Genet. 2017 Feb 17;13(2):e1006630
pubmed: 28212378
Nat Rev Genet. 2020 Oct;21(10):597-614
pubmed: 32504078
Front Genet. 2022 Apr 06;13:859513
pubmed: 35464862
Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188392
pubmed: 32735964
Nucleic Acids Res. 2005 Aug 09;33(14):4519-26
pubmed: 16091629
Cytogenet Genome Res. 2009;124(3-4):327-38
pubmed: 19556784
Ultrasound Obstet Gynecol. 2019 May;53(5):615-622
pubmed: 30125412
Science. 2012 Apr 6;336(6077):82-6
pubmed: 22403181
Nat Commun. 2021 Sep 20;12(1):5531
pubmed: 34545084
Bio Protoc. 2021 May 05;11(9):e4003
pubmed: 34124304
Nat Commun. 2018 Mar 14;9(1):1069
pubmed: 29540679
Trends Genet. 2022 Jul;38(7):766-781
pubmed: 35277298
Nat Cancer. 2022 Jul 14;:
pubmed: 35835961
Semin Cell Dev Biol. 2022 Aug;128:40-50
pubmed: 35292190
Mol Ecol. 2021 Nov;30(21):5360-5372
pubmed: 34637174
J Biol Chem. 2002 Aug 23;277(34):31031-7
pubmed: 12050166
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Annu Rev Pathol. 2022 Jan 24;17:367-386
pubmed: 34752712
Ann Transl Med. 2021 Sep;9(18):1464
pubmed: 34734016
Cell. 2013 Nov 7;155(4):934-47
pubmed: 24119843
PLoS One. 2020 Sep 9;15(9):e0233813
pubmed: 32903277
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188551
pubmed: 33892052
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1658-1665
pubmed: 31900366
Bioinformatics. 2021 Dec 09;:
pubmed: 34888626
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3114-22
pubmed: 26038577
Cell. 2013 Apr 11;153(2):320-34
pubmed: 23582323
Sci Rep. 2017 Sep 8;7(1):10968
pubmed: 28887493
Nat Med. 2011 Jul 17;17(8):996-1002
pubmed: 21765404
Cell. 2019 Nov 27;179(6):1330-1341.e13
pubmed: 31761532
PLoS Biol. 2019 Dec 3;17(12):e3000471
pubmed: 31794573
Genome Res. 2020 Dec;30(12):1695-1704
pubmed: 33122304
Comput Struct Biotechnol J. 2022 Jun 15;20:3059-3067
pubmed: 35782732
Cell Res. 2022 Sep 14;:
pubmed: 36104507
Clin Chem. 2021 Apr 29;67(5):788-796
pubmed: 33615350
Nat Commun. 2020 Sep 1;11(1):4374
pubmed: 32873787
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3332-3337
pubmed: 29531028
Epigenetics Chromatin. 2021 Aug 23;14(1):40
pubmed: 34425889
Cell. 2013 Apr 11;153(2):307-19
pubmed: 23582322
Nat Protoc. 2020 May;15(5):1673-1689
pubmed: 32246135
Methods Mol Biol. 2020;2119:165-181
pubmed: 31989524
Plant J. 2022 Jun;110(6):1811-1828
pubmed: 35426957
Nat Commun. 2021 Nov 11;12(1):6489
pubmed: 34764264
Trends Genet. 2018 Apr;34(4):270-278
pubmed: 29329720
PLoS One. 2017 Sep 6;12(9):e0184365
pubmed: 28877255
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1256-60
pubmed: 26787905
Proc Natl Acad Sci U S A. 1965 Feb;53:356-62
pubmed: 14294069
Nat Commun. 2019 Jan 23;10(1):392
pubmed: 30674876
J Struct Biol. 2002 Oct-Dec;140(1-3):167-79
pubmed: 12490165
Mol Biol Cell. 1999 Dec;10(12):4385-402
pubmed: 10588665
Nucleic Acids Res. 2019 Oct 10;47(18):9741-9760
pubmed: 31504770
Cell Rep. 2021 Mar 9;34(10):108814
pubmed: 33691114
BMC Bioinformatics. 2022 Jan 14;23(1):40
pubmed: 35030991
Mol Cancer. 2021 Sep 3;20(1):113
pubmed: 34479546
Epigenet Insights. 2020 Feb 28;13:2516865720904052
pubmed: 32166219
BMC Bioinformatics. 2019 Dec 12;20(1):663
pubmed: 31830908
JCI Insight. 2022 Apr 22;7(8):
pubmed: 35451374
Nucleic Acids Res. 2022 Jan 7;50(D1):D72-D82
pubmed: 34792166
Genome Biol Evol. 2020 Jan 1;12(1):3762-3777
pubmed: 31882998
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5477-82
pubmed: 18375758
Sci Rep. 2022 Mar 4;12(1):3590
pubmed: 35246593
Nat Genet. 2021 Dec;53(12):1673-1685
pubmed: 34782764
Sci Adv. 2020 May 15;6(20):eaba2489
pubmed: 32440553
Plant Cell. 2020 Jul;32(7):2132-2140
pubmed: 32327538
Int J Mol Sci. 2020 Apr 02;21(7):
pubmed: 32252492
Cancer Discov. 2022 Feb;12(2):468-483
pubmed: 34819316
Front Cell Dev Biol. 2022 Jan 06;9:792555
pubmed: 35083218
Front Plant Sci. 2021 Dec 01;12:743742
pubmed: 34925397
PLoS Genet. 2022 Mar 3;18(3):e1010024
pubmed: 35239675
Cytogenet Genome Res. 2016;148(2-3):237-40
pubmed: 27160259
BMC Res Notes. 2020 Jul 10;13(1):330
pubmed: 32650810
Front Immunol. 2021 Dec 21;12:780779
pubmed: 34992600
Science. 2015 Oct 2;350(6256):94-98
pubmed: 26430121
Trends Genet. 2009 Jul;25(7):298-307
pubmed: 19560228