Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.

Animals TRPC Cation Channels / genetics Reproducibility of Results Brain / metabolism Synaptic Transmission Mammals / metabolism
Ca(2+) signaling G-protein-coupled receptors TRP TRPC C mass spectrometry neurons patch clamp protein biochemistry proteomics transient receptor potential channels

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
21 12 2022
Historique:
received: 26 04 2022
revised: 15 08 2022
accepted: 23 09 2022
pubmed: 19 10 2022
medline: 27 12 2022
entrez: 18 10 2022
Statut: ppublish

Résumé

In the mammalian brain TRPC channels, a family of Ca

Identifiants

DOI: 10.1016/j.neuron.2022.09.029 PMID: 36257322
pubmed: 36257322
pii: S0896-6273(22)00868-6
doi: 10.1016/j.neuron.2022.09.029
pii:
doi:

Substances chimiques

TRPC Cation Channels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4162-4175.e7

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Astrid Kollewe (A)

Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 7, 79104 Freiburg, Germany.

Yvonne Schwarz (Y)

Institute of Physiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany.

Katharina Oleinikov (K)

Institute of Physiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany.

Ahsan Raza (A)

Experimental and Clinical Pharmacology and Toxicology, PZMS, Saarland University, 66421 Homburg, Germany.

Alexander Haupt (A)

Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 7, 79104 Freiburg, Germany.

Philipp Wartenberg (P)

Experimental and Clinical Pharmacology and Toxicology, PZMS, Saarland University, 66421 Homburg, Germany.

Amanda Wyatt (A)

Experimental and Clinical Pharmacology and Toxicology, PZMS, Saarland University, 66421 Homburg, Germany.

Ulrich Boehm (U)

Experimental and Clinical Pharmacology and Toxicology, PZMS, Saarland University, 66421 Homburg, Germany.

Fabien Ectors (F)

Transgenic facility, FARAH Research Center, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.

Wolfgang Bildl (W)

Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 7, 79104 Freiburg, Germany.

Gerd Zolles (G)

Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 7, 79104 Freiburg, Germany.

Uwe Schulte (U)

Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 7, 79104 Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, Schänzlestr. 18, 79104 Freiburg, Germany.

Dieter Bruns (D)

Institute of Physiology, Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany.

Veit Flockerzi (V)

Experimental and Clinical Pharmacology and Toxicology, PZMS, Saarland University, 66421 Homburg, Germany. Electronic address: veit.flockerzi@uks.eu.

Bernd Fakler (B)

Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 7, 79104 Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, Schänzlestr. 18, 79104 Freiburg, Germany; Center for Basics in NeuroModulation, Breisacherstr. 4, 79106 Freiburg, Germany. Electronic address: bernd.fakler@physiologie.uni-freiburg.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Subunit composition, molecular environment,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPC › Subunit composition, molecular environment,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Subunit composition, molecular environment,...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Subunit composition, molecular environment,...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Subunit composition, molecular environment,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Subunit composition, molecular environment,...