Depressive symptoms in cognitively unimpaired older adults are associated with lower structural and functional integrity in a frontolimbic network.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
25
09
2021
accepted:
30
08
2022
revised:
19
08
2022
pubmed:
19
10
2022
medline:
22
12
2022
entrez:
18
10
2022
Statut:
ppublish
Résumé
Subclinical depressive symptoms are associated with increased risk of Alzheimer's disease (AD), but the brain mechanisms underlying this relationship are still unclear. We aimed to provide a comprehensive overview of the brain substrates of subclinical depressive symptoms in cognitively unimpaired older adults using complementary multimodal neuroimaging data. We included cognitively unimpaired older adults from the baseline data of the primary cohort Age-Well (n = 135), and from the replication cohort ADNI (n = 252). In both cohorts, subclinical depressive symptoms were assessed using the 15-item version of the Geriatric Depression Scale; based on this scale, participants were classified as having depressive symptoms (>0) or not (0). Voxel-wise between-group comparisons were performed to highlight differences in gray matter volume, glucose metabolism and amyloid deposition; as well as white matter integrity (only available in Age-Well). Age-Well participants with subclinical depressive symptoms had lower gray matter volume in the hippocampus and lower white matter integrity in the fornix and the posterior parts of the cingulum and corpus callosum, compared to participants without symptoms. Hippocampal atrophy was recovered in ADNI, where participants with subclinical depressive symptoms also showed glucose hypometabolism in the hippocampus, amygdala, precuneus/posterior cingulate cortex, medial and dorsolateral prefrontal cortex, insula, and temporoparietal cortex. Subclinical depressive symptoms were not associated with brain amyloid deposition in either cohort. Subclinical depressive symptoms in ageing are linked with neurodegeneration biomarkers in the frontolimbic network including brain areas particularly sensitive to AD. The relationship between depressive symptoms and AD may be partly underpinned by neurodegeneration in common brain regions.
Identifiants
pubmed: 36258017
doi: 10.1038/s41380-022-01772-8
pii: 10.1038/s41380-022-01772-8
pmc: PMC9763117
doi:
Types de publication
Review
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5086-5095Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : CIHR
Pays : Canada
Investigateurs
Eider M Arenaza-Urquijo
(EM)
Florence Allais
(F)
Claire André
(C)
Julien Asselineau
(J)
Sebastian Baez Lugo
(S)
Martine Batchelor
(M)
Axel Beaugonin
(A)
Alexandre Bejanin
(A)
Pierre Champetier
(P)
Anne Chocat
(A)
Fabienne Collette
(F)
Sophie Dautricourt
(S)
Eglantine Ferrand-Devouge
(E)
Robin De Flores
(R)
Vincent De La Sayette
(V)
Pascal Delamillieure
(P)
Marion Delarue
(M)
Yacila I Deza-Araujo
(YI)
Hélène Esperou
(H)
Francesca Felisatti
(F)
Eric Frison
(E)
Francis Gheysen
(F)
Julie Gonneaud
(J)
Marc Heidmann
(M)
Thien Huong Tran
(T)
Frank Jessen
(F)
Pierre Krolak-Salmon
(P)
Gwendoline Le Du
(G)
Valérie Lefranc
(V)
Antoine Lutz
(A)
Jose-Luis Molinuevo
(JL)
Cassandre Palix
(C)
Léo Paly
(L)
Géraldine Rauchs
(G)
Stéphane Réhel
(S)
Florence Requier
(F)
Eric Salmon
(E)
Raquel Sanchez
(R)
Corinne Schimmer
(C)
Matthieu Vanhoutte
(M)
Patrik Vuilleumier
(P)
Caitlin Ware
(C)
Miranka Wirth
(M)
Informations de copyright
© 2022. The Author(s).
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