Kaempferol: A potential agent in the prevention of colorectal cancer.
anticancer
colorectal cancer
flavonol
kaempferol
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
20
09
2022
received:
09
07
2022
accepted:
21
09
2022
entrez:
19
10
2022
pubmed:
20
10
2022
medline:
21
10
2022
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo- and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase-1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non-cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC.
Identifiants
pubmed: 36259115
doi: 10.14814/phy2.15488
pmc: PMC9579739
doi:
Substances chimiques
Catalase
EC 1.11.1.6
Kaempferols
0
Reactive Oxygen Species
0
Heme Oxygenase-1
EC 1.14.14.18
Superoxides
11062-77-4
Xanthine Oxidase
EC 1.17.3.2
Peroxynitrous Acid
14691-52-2
Superoxide Dismutase
EC 1.15.1.1
Reactive Nitrogen Species
0
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15488Informations de copyright
© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Références
Int J Pharm. 2011 Nov 25;420(1):1-10
pubmed: 21884771
Int J Food Sci Nutr. 2007 Jun;58(4):261-9
pubmed: 17566888
Br J Cancer. 2017 Jan;116(3):389-397
pubmed: 28056465
Pharmazie. 2014 Jan;69(1):19-26
pubmed: 24601218
Nutrients. 2017 Nov 30;9(12):
pubmed: 29189718
J Pharmacol Exp Ther. 2000 Sep;294(3):837-43
pubmed: 10945831
Int J Food Sci Nutr. 2017 Sep;68(6):704-711
pubmed: 28114854
Microb Cell Fact. 2017 Sep 26;16(1):165
pubmed: 28950867
J Agric Food Chem. 2016 Oct 26;64(42):7966-7972
pubmed: 27730814
Adv Mater. 2010 Oct 8;22(38):4293-7
pubmed: 20564713
J Med Food. 2020 Jan;23(1):50-55
pubmed: 31441682
Carcinogenesis. 2005 Mar;26(3):665-71
pubmed: 15618237
Int J Pharm. 2019 Oct 30;570:118642
pubmed: 31446024
Eur J Nutr. 2003 Jan;42(1):29-42
pubmed: 12594539
Drug Res (Stuttg). 2014 Oct;64(10):516-22
pubmed: 24357136
Int J Pharm. 2009 Feb 9;367(1-2):58-64
pubmed: 18848870
Cancer Lett. 1997 Mar 19;114(1-2):173-4
pubmed: 9103283
Data Brief. 2018 Oct 27;21:1033-1036
pubmed: 30450396
Gastroenterology. 2016 Apr;150(4):808-10
pubmed: 26924087
Int J Mol Sci. 2021 Jul 12;22(14):
pubmed: 34299082
PLoS One. 2014 Feb 06;9(2):e87766
pubmed: 24516562
Science. 1997 Aug 8;277(5327):815-8
pubmed: 9242610
Nutrients. 2019 Oct 05;11(10):
pubmed: 31590362
Mol Cancer. 2003 Dec 12;2:41
pubmed: 14672538
Int J Pharm. 2019 Jun 30;565:488-498
pubmed: 31100382
J Am Chem Soc. 2002 May 29;124(21):5952-3
pubmed: 12022823
Biochem Biophys Res Commun. 2008 Oct 10;375(1):129-33
pubmed: 18680719
Eur J Clin Nutr. 2004 Jun;58(6):947-54
pubmed: 15164116
Sci Rep. 2019 Jan 17;9(1):195
pubmed: 30655588
Metab Eng. 2016 May;35:55-63
pubmed: 26860871
Cell Death Differ. 2003 Jan;10(1):66-75
pubmed: 12655296
Phytother Res. 2010 Sep;24(9):1302-8
pubmed: 20104502
Food Chem. 2015 Sep 15;183:30-5
pubmed: 25863606
FEBS Lett. 1998 Sep 25;436(1):71-5
pubmed: 9771896
Molecules. 2020 Sep 07;25(18):
pubmed: 32906577
Crit Rev Food Sci Nutr. 2022 Apr 25;:1-25
pubmed: 35468008
Biotechnol Bioeng. 2013 Sep;110(9):2525-35
pubmed: 23568509
J Clin Invest. 1999 Jul;104(2):155-62
pubmed: 10411544
J Cell Physiol. 2019 Aug;234(8):12369-12384
pubmed: 30605237
World Neurosurg. 2018 May;113:e508-e514
pubmed: 29476996
Toxicol In Vitro. 2001 Feb;15(1):3-6
pubmed: 11259863
Science. 1997 Aug 8;277(5327):818-21
pubmed: 9242611
Eur J Med Chem. 2014 Oct 30;86:103-12
pubmed: 25147152
Int J Oncol. 2013 Jun;42(6):2069-77
pubmed: 23591552
Nat Med. 1999 Feb;5(2):157-63
pubmed: 9930862
J Agric Food Chem. 2006 Dec 27;54(26):9798-804
pubmed: 17177504
AAPS PharmSciTech. 2011 Mar;12(1):62-76
pubmed: 21174180
Drug Metab Dispos. 2002 May;30(5):576-81
pubmed: 11950790
Radiat Environ Biophys. 2014 Nov;53(4):695-704
pubmed: 24981250
Arch Pharm Res. 2021 Dec;44(12):1091-1108
pubmed: 34750753
Compr Rev Food Sci Food Saf. 2018 Sep;17(5):1054-1112
pubmed: 33350159
Chem Biol Interact. 2009 Jan 27;177(2):121-7
pubmed: 19028473
Pathol Res Pract. 2022 May;233:153885
pubmed: 35428017
Eur J Pharm Biopharm. 2000 Jul;50(1):47-60
pubmed: 10840192
J Pharm Sci. 2010 Feb;99(2):598-617
pubmed: 19544374
Discov Med. 2010 Feb;9(45):145-52
pubmed: 20193641
J Drug Target. 2017 Jul;25(6):499-512
pubmed: 28151021
Hortic Res. 2021 Aug 1;8(1):173
pubmed: 34333541
Eur J Pharmacol. 2021 Sep 5;906:174270
pubmed: 34171392
J Cancer Prev. 2013 Sep;18(3):257-63
pubmed: 25337553
Eur J Pharmacol. 2011 Mar 1;654(1):75-9
pubmed: 21172346
Physiol Rep. 2022 Oct;10(20):e15488
pubmed: 36259115
J Biochem Mol Toxicol. 2018 Oct;32(10):e22198
pubmed: 29999212
Molecules. 2019 Jun 19;24(12):
pubmed: 31248102
Adv Drug Deliv Rev. 2007 Jul 30;59(7):677-94
pubmed: 17628203
Chin J Cancer. 2016 Jan 06;35:4
pubmed: 26738600
Phytother Res. 2019 Feb;33(2):263-275
pubmed: 30402931
Ann Ist Super Sanita. 2007;43(4):348-61
pubmed: 18209268
Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G980-8
pubmed: 12736148
Front Oncol. 2019 Apr 10;9:227
pubmed: 31024836
Cold Spring Harb Perspect Biol. 2013 Sep 01;5(9):
pubmed: 24003211
Int J Mol Sci. 2019 Mar 09;20(5):
pubmed: 30857282
Biotechnol Adv. 2014 Nov 1;32(6):1145-56
pubmed: 24780153
Metab Eng. 2017 Mar;40:115-123
pubmed: 28111248
J Agric Food Chem. 2021 Mar 17;69(10):3060-3068
pubmed: 33663206
Life Sci. 2020 Oct 15;259:118255
pubmed: 32818543
Int J Mol Sci. 2022 Mar 24;23(7):
pubmed: 35408903
Molecules. 2010 Oct 21;15(10):7313-52
pubmed: 20966876
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Annu Rev Pharmacol Toxicol. 2004;44:239-67
pubmed: 14744246
J Pharmacol Sci. 2021 Jan;145(1):29-41
pubmed: 33357777
Int J Mol Sci. 2014 Feb 17;15(2):2722-37
pubmed: 24549175
Nutrients. 2017 Nov 29;9(12):
pubmed: 29186068
Eur J Intern Med. 2015 Dec;26(10):752-6
pubmed: 26499755
Br J Nutr. 2010 Jan;103(2):249-55
pubmed: 19747418
Phytother Res. 2010 Jan;24 Suppl 1:S77-82
pubmed: 19585476
World J Gastroenterol. 2017 Jul 28;23(28):5086-5096
pubmed: 28811705
J Clin Invest. 2015 Sep;125(9):3335-7
pubmed: 26325031
J Agric Food Chem. 2010 Jan 13;58(1):620-7
pubmed: 20050706
Nat Rev Cancer. 2009 Jun;9(6):400-14
pubmed: 19440234