Two firing modes and well-resolved Na
AP-clamp recording
Cell-electrode interface
Extracellular action potentials
Ion channel blockers
Na+, Ca2+, and K+ currents
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
04
08
2022
accepted:
07
10
2022
revised:
23
09
2022
pubmed:
20
10
2022
medline:
21
1
2023
entrez:
19
10
2022
Statut:
ppublish
Résumé
We recorded spontaneous extracellular action potentials (eAPs) from rat chromaffin cells (CCs) at 37 °C using microelectrode arrays (MEAs) and compared them with intracellularly recorded APs (iAPs) through conventional patch clamp recordings at 22 °C. We show the existence of two distinct firing modes on MEAs: a ~ 4 Hz irregular continuous firing and a frequent intermittent firing mode where periods of high-intraburst frequency (~ 8 Hz) of ~ 7 s duration are interrupted by silent periods of ~ 12 s. eAPs occurred either as negative- or positive-going signals depending on the contact between cell and microelectrode: either predominantly controlled by junction-membrane ion channels (negative-going) or capacitive/ohmic coupling (positive-going). Negative-going eAPs were found to represent the trajectory of the Na
Identifiants
pubmed: 36260174
doi: 10.1007/s00424-022-02761-0
pii: 10.1007/s00424-022-02761-0
pmc: PMC9849155
doi:
Substances chimiques
Large-Conductance Calcium-Activated Potassium Channels
0
Ion Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-202Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
Références
Compr Physiol. 2019 Sep 19;9(4):1443-1502
pubmed: 31688964
Adv Biosyst. 2019 Feb;3(2):e1800308
pubmed: 30882024
Neurosignals. 2012;20(4):252-64
pubmed: 22286202
J Neurochem. 2015 May;133(4):511-21
pubmed: 25683177
Chaos. 2011 Dec;21(4):047510
pubmed: 22225384
PLoS One. 2012;7(7):e41530
pubmed: 22848520
J Physiol. 1949 Aug;109(1-2):240-9
pubmed: 15394322
Front Neural Circuits. 2012 May 14;6:28
pubmed: 22593736
Eur J Neurosci. 1999 Oct;11(10):3574-84
pubmed: 10564365
J Physiol. 2003 Apr 1;548(Pt 1):191-202
pubmed: 12576496
J Physiol. 1980 Oct;307:199-216
pubmed: 7205664
J Physiol. 1992;453:97-131
pubmed: 1464851
J Physiol. 2017 Apr 15;595(8):2587-2609
pubmed: 28026020
Cell Calcium. 2012 Mar-Apr;51(3-4):321-30
pubmed: 22317919
Q J Exp Physiol. 1982 Jan;67(1):41-55
pubmed: 6281846
Pflugers Arch. 2018 Jan;470(1):89-96
pubmed: 28735418
J Physiol Sci. 2017 Sep;67(5):549-560
pubmed: 28656459
Biophys J. 2006 Jan 1;90(1):183-9
pubmed: 16227504
J Physiol. 2021 Mar;599(6):1855-1883
pubmed: 33450050
J Neurosci Methods. 1989 Nov;30(2):91-106
pubmed: 2586157
J Neurosci. 1995 Sep;15(9):6110-23
pubmed: 7545225
Korean J Physiol Pharmacol. 2020 Jul 1;24(4):349-362
pubmed: 32587129
Physiol Rev. 2006 Oct;86(4):1093-131
pubmed: 17015485
J Gen Physiol. 2014 Oct;144(4):275-95
pubmed: 25267913
Acta Physiol (Oxf). 2008 Feb;192(2):213-20
pubmed: 18021321
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1146-1151
pubmed: 30617062
Front Cell Neurosci. 2011 Jan 25;5:1
pubmed: 21286222
Science. 1992 Sep 18;257(5077):1694-8
pubmed: 1529355
J Gen Physiol. 2021 Apr 5;153(4):
pubmed: 33651884
Cereb Cortex. 2018 Jul 1;28(7):2594-2609
pubmed: 29790938
J Gen Physiol. 1970 Jan;55(1):104-18
pubmed: 5410485
Am Sci. 1973 Nov-Dec;61(6):692-9
pubmed: 4746051
Naunyn Schmiedebergs Arch Pharmacol. 1993 Oct;348(4):379-84
pubmed: 7904052
Eur J Neurosci. 1998 Jun;10(6):1956-62
pubmed: 9753082
Acta Physiol (Oxf). 2008 Feb;192(2):221-31
pubmed: 18021327
Nat Rev Neurosci. 2012 May 18;13(6):407-20
pubmed: 22595786
J Neurophysiol. 1999 May;81(5):2267-78
pubmed: 10322065
Cell Mol Neurobiol. 2010 Nov;30(8):1433-40
pubmed: 21061156
PLoS Biol. 2010 Aug 31;8(8):
pubmed: 20824168
J Neurosci. 2012 Nov 14;32(46):16345-59
pubmed: 23152617
Science. 1991 May 31;252(5010):1290-3
pubmed: 1925540
J Neurosci. 2010 Jan 13;30(2):491-504
pubmed: 20071512
J Physiol. 2007 Oct 1;584(Pt 1):149-65
pubmed: 17690152
Biophys J. 2003 Aug;85(2):1326-37
pubmed: 12885675
J Neurosci. 2003 Jan 1;23(1):73-83
pubmed: 12514203
J Physiol. 1963 Nov;169:431-7
pubmed: 14079679
J Neurophysiol. 2006 May;95(5):3113-28
pubmed: 16467426
J Gen Physiol. 2014 Nov;144(5):415-40
pubmed: 25348413
Int Rev Neurobiol. 2016;128:439-75
pubmed: 27238271
Biosystems. 2019 Jun;180:1-6
pubmed: 30862447
J Neurosci. 2008 Jun 25;28(26):6616-26
pubmed: 18579734
Mol Brain. 2014 Jul 22;7:50
pubmed: 25051923
Front Neurosci. 2015 Jan 06;8:423
pubmed: 25610364
J Physiol. 2015 Feb 15;593(4):905-27
pubmed: 25620605
Cogn Neurodyn. 2022 Apr;16(2):411-423
pubmed: 35401866
J Gen Physiol. 1967 Jul;50(6):1469-84
pubmed: 6034753
J Neurophysiol. 1996 Aug;76(2):1195-211
pubmed: 8871230
Nat Commun. 2013;4:2938
pubmed: 24356378
Front Neurosci. 2016 Jun 21;10:282
pubmed: 27445657
Mol Neurobiol. 2010 Dec;42(3):185-98
pubmed: 21088933
Cereb Cortex. 2018 Feb 1;28(2):433-446
pubmed: 27999123
J Physiol. 2019 Mar;597(6):1705-1733
pubmed: 30629744
J Neurosci Methods. 2002 May 30;117(1):13-21
pubmed: 12084560
Nat Commun. 2013;4:2181
pubmed: 23867868
Pflugers Arch. 2018 Jan;470(1):39-52
pubmed: 28776261
Front Cell Neurosci. 2019 Apr 26;13:159
pubmed: 31118887
J Physiol. 2004 Jul 15;558(Pt 2):433-49
pubmed: 15133061
Physiol Rep. 2016 Sep;4(17):
pubmed: 27597763
Anal Bioanal Chem. 2003 Oct;377(3):486-95
pubmed: 12923608
J Physiol. 1979 Apr;289:479-500
pubmed: 458684
Cell Calcium. 2007 Oct-Nov;42(4-5):397-408
pubmed: 17561252
Eur Biophys J. 1999;28(3):254-8
pubmed: 10192937
FASEB J. 2003 Feb;17(2):330-2
pubmed: 12490549