Manipulation by Plasmodium Parasites of Anopheles Mosquito Behavior and Human Odors.
Malaria
Manipulation of host odor
Transmissible stages
Volatile organic compounds
Journal
Acta parasitologica
ISSN: 1896-1851
Titre abrégé: Acta Parasitol
Pays: Switzerland
ID NLM: 9301947
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
08
08
2022
accepted:
20
09
2022
pubmed:
20
10
2022
medline:
1
12
2022
entrez:
19
10
2022
Statut:
ppublish
Résumé
The phenomenon of parasites manipulating host phenotypes is well documented; the best-known examples are manipulations of host behavior. More recently, there has been interest in whether parasites can manipulate host odor phenotypes to enhance their attractiveness to vectors. We review here evidence that Plasmodium-infected mosquitoes have enhanced attraction to human hosts, especially when the parasite is sufficiently developed to be transmissible. We also review evidence suggesting that malaria-infected host odors elicit greater mosquito attraction compared to uninfected controls. We reviewed and summarized the relevant literature. Though evidence is mounting that supports both premises we reviewed, there are several confounds that complicate interpretation. These include differences in Plasmodium and mosquito species studied, stage of infection tested, age of human participants in trials, and methods used to quantify volatiles. In addition, a key requirement to support the hypothesis of manipulation by parasites is that costs of manipulation be identified, and ideally, quantified. Substantial progress has been made to unlock the importance of odor for enhancing transmission of Plasmodium. However, there needs to be more replication using similar methods to better define the odor parameters involved in this enhancement.
Identifiants
pubmed: 36260195
doi: 10.1007/s11686-022-00621-6
pii: 10.1007/s11686-022-00621-6
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1463-1470Informations de copyright
© 2022. The Author(s) under exclusive licence to Witold Stefański Institute of Parasitology, Polish Academy of Sciences.
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