Investigation of the immune escape mechanism of Treponema pallidum.
Immune escape
Immune response
Outer membrane
Tpr
Treponema pallidum
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
25
03
2022
accepted:
07
10
2022
medline:
29
3
2023
pubmed:
20
10
2022
entrez:
19
10
2022
Statut:
ppublish
Résumé
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subspecies pallidum (T. pallidum), which is a public health problem that seriously affects human health worldwide. T. pallidum is characterized by early transmission and immune escape and is therefore termed an "invisible pathogen". This review systematically summarizes the host's innate and adaptive immune responses to T. pallidum infection as well as the escape mechanisms of T. pallidum. To lay the foundation for assessing the pathogenic mechanism and the systematic prevention and treatment of syphilis. The immune escape mechanism of T. pallidum plays an important role in its survival. Exploring the occurrence and development of these mechanisms has laid the foundation for the development of syphilis vaccine.
Sections du résumé
BACKGROUND
BACKGROUND
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subspecies pallidum (T. pallidum), which is a public health problem that seriously affects human health worldwide. T. pallidum is characterized by early transmission and immune escape and is therefore termed an "invisible pathogen".
METHODS
METHODS
This review systematically summarizes the host's innate and adaptive immune responses to T. pallidum infection as well as the escape mechanisms of T. pallidum.
PURPOSE
OBJECTIVE
To lay the foundation for assessing the pathogenic mechanism and the systematic prevention and treatment of syphilis.
CONCLUSION
CONCLUSIONS
The immune escape mechanism of T. pallidum plays an important role in its survival. Exploring the occurrence and development of these mechanisms has laid the foundation for the development of syphilis vaccine.
Identifiants
pubmed: 36260281
doi: 10.1007/s15010-022-01939-z
pii: 10.1007/s15010-022-01939-z
doi:
Substances chimiques
Bacterial Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
305-321Subventions
Organisme : Natural Science Foundation of Hunan Province
ID : 2022JJ30532
Organisme : Hunan Provincial Innovation University of South China Innovation Foundation for Postgraduate
ID : 213YXC016
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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