Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
13 Oct 2022
13 Oct 2022
Historique:
received:
19
07
2022
accepted:
22
09
2022
entrez:
20
10
2022
pubmed:
21
10
2022
medline:
21
10
2022
Statut:
epublish
Résumé
Protein S-acylation is a dynamic and reversible lipid post-translational modification that can affect the activity, stability, localization, and interactions of target proteins. Lipid modification occurs on cysteine residues via a thioester bond and in humans is mediated by 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs). The DHHC-PATs have well-known roles in physiology and disease, but much remains to be discovered about their biological function and therapeutic potential. We recently developed cyanomyracrylamide (
Identifiants
pubmed: 36262404
doi: 10.1021/acsmedchemlett.2c00336
pmc: PMC9575173
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1648-1654Subventions
Organisme : NIDDK NIH HHS
ID : F30 DK125088
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119840
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007281
Pays : United States
Informations de copyright
© 2022 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8403-E8412
pubmed: 30127002
PLoS One. 2013 Oct 02;8(10):e75232
pubmed: 24098372
J Mol Biol. 2020 Aug 21;432(18):4983-4998
pubmed: 32522557
ACS Chem Biol. 2021 Aug 20;16(8):1546-1556
pubmed: 34309372
Biochem Soc Trans. 2017 Aug 15;45(4):923-8
pubmed: 28630137
FEBS J. 2022 Feb;289(4):861-882
pubmed: 33624421
Science. 2018 Jan 12;359(6372):
pubmed: 29326245
Acc Chem Res. 2019 Nov 19;52(11):3029-3038
pubmed: 31577124
Curr Opin Chem Biol. 2015 Feb;24:48-57
pubmed: 25461723
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):
pubmed: 35140179
Trends Biochem Sci. 2017 Jul;42(7):566-581
pubmed: 28602500
Curr Opin Chem Biol. 2021 Dec;65:118-125
pubmed: 34467875
Chem Sci. 2019 Jul 1;10(39):8995-9000
pubmed: 31762980
ACS Chem Biol. 2013 Sep 20;8(9):1912-7
pubmed: 23844586
ACS Omega. 2019 May 31;4(5):8274-8281
pubmed: 31172038
J Chem Neuroanat. 2017 Oct;83-84:3-9
pubmed: 28115272
Front Mol Biosci. 2021 Mar 17;8:659861
pubmed: 33816563