Detection of anti-desmoglein antibodies in oral lichen planus: What do we know so far.
autoantibodies
desmoglein
epitope spreading
oral lichen planus
pemphigus vulgaris
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
07
2022
accepted:
14
09
2022
entrez:
20
10
2022
pubmed:
21
10
2022
medline:
22
10
2022
Statut:
epublish
Résumé
Oral lichen planus (OLP) is an inflammatory disease of the oral mucosa. Clinically, two main subsets are described, namely non-erosive and erosive OLP. While non-erosive OLP is usually responsive to local therapies, erosive OLP is often refractory also to systemic therapies and extremely reduces the quality of life of the patients. Furthermore, in some erosive OLP cases different autoantibodies have been detected, including anti-desmoglein 1 and 3 autoantibodies, and anti-bullous pemphigoid 180 and 230 autoantibodies. However, their potential role is still not clear. In this paper, we reviewed the literature about the detection of autoantibodies against desmoglein 1 and 3, the main target antigens of pemphigus vulgaris, in patient with OLP, summarizing the more recent insights on this topic.
Identifiants
pubmed: 36263026
doi: 10.3389/fimmu.2022.1001970
pmc: PMC9575987
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1001970Informations de copyright
Copyright © 2022 Didona and Hertl.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Allergy Clin Immunol. 2018 Aug;142(2):669-672.e7
pubmed: 29626572
J Dermatol. 2016 Nov;43(11):1350-1353
pubmed: 27458049
Front Med (Lausanne). 2022 Jun 09;9:875492
pubmed: 35755063
Front Immunol. 2018 Apr 17;9:779
pubmed: 29719538
Int J Dermatol. 2015 Sep;54(9):1005-10
pubmed: 26147778
BMC Oral Health. 2022 May 6;22(1):161
pubmed: 35524296
J Dermatol. 2015 Jan;42(1):40-1
pubmed: 25354571
Front Immunol. 2019 Jun 25;10:1418
pubmed: 31293582
Eur J Dermatol. 2007 Jan-Feb;17(1):4-11
pubmed: 17324820
Croat Med J. 2006 Feb;47(1):53-8
pubmed: 16489697
Arch Dermatol Res. 2016 Oct;308(8):539-51
pubmed: 27349424
Front Immunol. 2019 Jul 31;10:1808
pubmed: 31417572
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Jun;99(6):696-703
pubmed: 15897856
Ital J Dermatol Venerol. 2021 Apr;156(2):121-123
pubmed: 33314892
J Dtsch Dermatol Ges. 2021 Jun;19(6):864-882
pubmed: 34096678
Arch Dermatol Res. 2017 Sep;309(7):579-583
pubmed: 28674915
Dermatologie (Heidelb). 2022 Sep;73(9):692-700
pubmed: 36006424
Indian J Dermatol Venereol Leprol. 2018 Nov-Dec;84(6):667-671
pubmed: 30058559
Int J Dermatol. 2016 Jun;55(6):634-9
pubmed: 26567062