Coronavirus Host Genomics Study: South Africa (COVIGen-SA).
Journal
Global health, epidemiology and genomics
ISSN: 2054-4200
Titre abrégé: Glob Health Epidemiol Genom
Pays: England
ID NLM: 101703450
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
03
2022
revised:
04
07
2022
accepted:
08
07
2022
entrez:
20
10
2022
pubmed:
21
10
2022
medline:
22
10
2022
Statut:
epublish
Résumé
Host genetic factors are known to modify the susceptibility, severity, and outcomes of COVID-19 and vary across populations. However, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa's response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA-a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. Through this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. This project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities.
Identifiants
pubmed: 36263375
doi: 10.1155/2022/7405349
pmc: PMC9560830
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7405349Subventions
Organisme : Wellcome Trust
ID : 221003/Z/20/Z
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U54 HG006938
Pays : United States
Informations de copyright
Copyright © 2022 Andrew K. May et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
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