High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI.
FiO2
GFAP
GOSE
Mortality
PaO2
Traumatic brain injury
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
21
06
2022
accepted:
17
08
2022
pubmed:
21
10
2022
medline:
1
12
2022
entrez:
20
10
2022
Statut:
ppublish
Résumé
The effect of high arterial oxygen levels and supplemental oxygen administration on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI patients are limited. We investigated whether exposure to high blood oxygen levels and high oxygen supplementation is independently associated with outcomes in TBI patients admitted to the intensive care unit (ICU) and undergoing mechanical ventilation. This is a secondary analysis of two multicenter, prospective, observational, cohort studies performed in Europe and Australia. In TBI patients admitted to ICU, we describe the arterial partial pressure of oxygen (PaO The analysis included 1084 patients (11,577 measurements) in the CENTER-TBI cohort, of whom 55% had an unfavorable outcome, and 26% died at a 6-month follow-up. Median PaO In two large prospective multicenter cohorts of critically ill patients with TBI, levels of PaO
Identifiants
pubmed: 36264365
doi: 10.1007/s00134-022-06884-x
pii: 10.1007/s00134-022-06884-x
pmc: PMC9705485
doi:
Substances chimiques
Oxygen
S88TT14065
Banques de données
ClinicalTrials.gov
['NCT02210221']
Types de publication
Observational Study
Multicenter Study
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1709-1725Investigateurs
Cecilia Ackerlund
(C)
Krisztina Amrein
(K)
Nada Andelic
(N)
Lasse Andreassen
(L)
Audny Anke
(A)
Gérard Audibert
(G)
Philippe Azouvi
(P)
Maria Luisa Azzolini
(ML)
Ronald Bartels
(R)
Ronny Beer
(R)
Bo-Michael Bellander
(BM)
Habib Benali
(H)
Maurizio Berardino
(M)
Luigi Beretta
(L)
Erta Beqiri
(E)
Morten Blaabjerg
(M)
Stine Borgen Lund
(SB)
Camilla Brorsson
(C)
Andras Buki
(A)
Manuel Cabeleira
(M)
Alessio Caccioppola
(A)
Emiliana Calappi
(E)
Maria Rosa Calvi
(MR)
Peter Cameron
(P)
Guillermo Carbayo Lozano
(GC)
Marco Carbonara
(M)
Ana M Castaño-León
(AM)
Simona Cavallo
(S)
Giorgio Chevallard
(G)
Arturo Chieregato
(A)
Giuseppe Citerio
(G)
Hans Clusmann
(H)
Mark Steven Coburn
(MS)
Jonathan Coles
(J)
Jamie D Cooper
(JD)
Marta Correia
(M)
Endre Czeiter
(E)
Marek Czosnyka
(M)
Claire Dahyot-Fizelier
(C)
Paul Dark
(P)
Véronique Keyser
(V)
Vincent Degos
(V)
Francesco Della Corte
(FD)
Hugo Boogert
(H)
Bart Depreitere
(B)
Đula Đilvesi
(Đ)
Abhishek Dixit
(A)
Jens Dreier
(J)
Guy-Loup Dulière
(GL)
Ari Ercole
(A)
Erzsébet Ezer
(E)
Martin Fabricius
(M)
Kelly Foks
(K)
Shirin Frisvold
(S)
Alex Furmanov
(A)
Damien Galanaud
(D)
Dashiell Gantner
(D)
Alexandre Ghuysen
(A)
Lelde Giga
(L)
Jagoš Golubović
(J)
Pedro A Gomez
(PA)
Benjamin Gravesteijn
(B)
Francesca Grossi
(F)
Deepak Gupta
(D)
Iain Haitsma
(I)
Raimund Helbok
(R)
Eirik Helseth
(E)
Jilske Huijben
(J)
Peter J Hutchinson
(PJ)
Stefan Jankowski
(S)
Faye Johnson
(F)
Mladen Karan
(M)
Angelos G Kolias
(AG)
Daniel Kondziella
(D)
Evgenios Kornaropoulos
(E)
Lars-Owe Koskinen
(LO)
Noémi Kovács
(N)
Ana Kowark
(A)
Alfonso Lagares
(A)
Steven Laureys
(S)
Aurelie Lejeune
(A)
Fiona Lecky
(F)
Didier Ledoux
(D)
Roger Lightfoot
(R)
Hester Lingsma
(H)
Andrew I R Maas
(AIR)
Alex Manara
(A)
Hugues Maréchal
(H)
Costanza Martino
(C)
Julia Mattern
(J)
Catherine McMahon
(C)
David Menon
(D)
Tomas Menovsky
(T)
Benoit Misset
(B)
Visakh Muraleedharan
(V)
Lynnette Murray
(L)
Ancuta Negru
(A)
David Nelson
(D)
Virginia Newcombe
(V)
József Nyirádi
(J)
Fabrizio Ortolano
(F)
Jean-François Payen
(JF)
Vincent Perlbarg
(V)
Paolo Persona
(P)
Wilco Peul
(W)
Anna Piippo-Karjalainen
(A)
Horia Ples
(H)
Inigo Pomposo
(I)
Jussi P Posti
(JP)
Louis Puybasset
(L)
Andreea Rădoi
(A)
Arminas Ragauskas
(A)
Rahul Raj
(R)
Jonathan Rhodes
(J)
Sophie Richter
(S)
Saulius Rocka
(S)
Cecilie Roe
(C)
Olav Roise
(O)
Jeffrey Rosenfeld
(J)
Christina Rosenlund
(C)
Guy Rosenthal
(G)
Rolf Rossaint
(R)
Sandra Rossi
(S)
Juan Sahuquillo
(J)
Oliver Sakowitz
(O)
Renan Sanchez-Porras
(R)
Oddrun Sandrød
(O)
Kari Schirmer-Mikalsen
(K)
Rico Frederik Schou
(RF)
Charlie Sewalt
(C)
Peter Smielewski
(P)
Abayomi Sorinola
(A)
Emmanuel Stamatakis
(E)
Ewout W Steyerberg
(EW)
Nino Stocchetti
(N)
Nina Sundström
(N)
Riikka Takala
(R)
Viktória Tamás
(V)
Tomas Tamosuitis
(T)
Olli Tenovuo
(O)
Matt Thomas
(M)
Dick Tibboel
(D)
Christos Tolias
(C)
Tony Trapani
(T)
Cristina Maria Tudora
(CM)
Andreas Unterberg
(A)
Peter Vajkoczy
(P)
Egils Valeinis
(E)
Shirley Vallance
(S)
Zoltán Vámos
(Z)
Gregory Steen
(G)
T J M van Dijck Jeroen
(TJMVD)
Thomas A Essen
(TA)
Roel Wijk
(R)
Alessia Vargiolu
(A)
Emmanuel Vega
(E)
Anne Vik
(A)
Rimantas Vilcinis
(R)
Victor Volovici
(V)
Peter Vulekovic
(P)
Eveline Wiegers
(E)
Guy Williams
(G)
Stefan Winzeck
(S)
Stefan Wolf
(S)
Alexander Younsi
(A)
Frederick A Zeiler
(FA)
Agate Ziverte
(A)
Tommaso Zoerle
(T)
Jamie Cooper
(J)
Dashiell Gantner
(D)
Russel Gruen
(R)
Lynette Murray
(L)
Jeffrey V Rosenfeld
(JV)
Dinesh Varma
(D)
Tony Trapani
(T)
Shirley Vallance
(S)
Christopher MacIsaac
(C)
Andrea Jordan
(A)
Commentaires et corrections
Type : CommentOn
Type : CommentIn
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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