Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology.


Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2022
Historique:
received: 16 05 2022
accepted: 08 08 2022
entrez: 20 10 2022
pubmed: 21 10 2022
medline: 25 10 2022
Statut: epublish

Résumé

The pathophysiology of COVID-19 remains poorly understood. We aimed to estimate the contribution of intrapulmonary shunting and ventilation-to-perfusion (VA/Q) mismatch using a mathematical model to construct oxygen-haemoglobin dissociation curves (ODCs). ODCs were constructed using transcutaneous pulse oximetry at two different fractions of inspired oxygen (FiO2). 199 patients were included from two large district general hospitals in the South East of England from 1st to 14th January 2021. The study was supported by the National Institute of Health Research (NIHR) Clinical Research Network. Overall mortality was 29%. Mean age was 68.2 years (SEM 1·2) with 46% female. Median shunt on admission was 17% (IQR 8-24.5); VA/Q was 0.61 (IQR 0.52-0.73). Shunt was 37.5% higher in deaths (median 22%, IQR 9-29) compared to survivors (16%, 8-21; p = 0.0088) and was a predictor of mortality (OR 1.04; 95% CI 1.01-1.07). Admission oxygen saturations were more strongly predictive of mortality (OR 0.91, 95% CI 0.87-0.96). There was no difference in VA/Q mismatch between deaths (0.60; IQR 0.50-0.73) and survivors (0.61; IQR 0.52-0.73; p = 0.63) and it was not predictive of mortality (OR 0.68; 95% CI 0.18-2.52; p = 0.55). Shunt negatively correlated with admission oxygen saturation (R -0.533; p<0.0001) whereas VA/Q was not (R 0.1137; p = 0.12). Shunt, not VA/Q mismatch, was associated with worsening hypoxia, though calculating shunt was not of prognostic value. This study adds to our understanding of the pathophysiology of hypoxaemia in COVID-19. Our inexpensive and reliable technique may provide further insights into the pathophysiology of hypoxia in other respiratory diseases.

Sections du résumé

BACKGROUND
The pathophysiology of COVID-19 remains poorly understood. We aimed to estimate the contribution of intrapulmonary shunting and ventilation-to-perfusion (VA/Q) mismatch using a mathematical model to construct oxygen-haemoglobin dissociation curves (ODCs).
METHODS
ODCs were constructed using transcutaneous pulse oximetry at two different fractions of inspired oxygen (FiO2). 199 patients were included from two large district general hospitals in the South East of England from 1st to 14th January 2021. The study was supported by the National Institute of Health Research (NIHR) Clinical Research Network.
RESULTS
Overall mortality was 29%. Mean age was 68.2 years (SEM 1·2) with 46% female. Median shunt on admission was 17% (IQR 8-24.5); VA/Q was 0.61 (IQR 0.52-0.73). Shunt was 37.5% higher in deaths (median 22%, IQR 9-29) compared to survivors (16%, 8-21; p = 0.0088) and was a predictor of mortality (OR 1.04; 95% CI 1.01-1.07). Admission oxygen saturations were more strongly predictive of mortality (OR 0.91, 95% CI 0.87-0.96). There was no difference in VA/Q mismatch between deaths (0.60; IQR 0.50-0.73) and survivors (0.61; IQR 0.52-0.73; p = 0.63) and it was not predictive of mortality (OR 0.68; 95% CI 0.18-2.52; p = 0.55). Shunt negatively correlated with admission oxygen saturation (R -0.533; p<0.0001) whereas VA/Q was not (R 0.1137; p = 0.12).
INTERPRETATION
Shunt, not VA/Q mismatch, was associated with worsening hypoxia, though calculating shunt was not of prognostic value. This study adds to our understanding of the pathophysiology of hypoxaemia in COVID-19. Our inexpensive and reliable technique may provide further insights into the pathophysiology of hypoxia in other respiratory diseases.

Identifiants

pubmed: 36264932
doi: 10.1371/journal.pone.0273402
pii: PONE-D-22-14285
pmc: PMC9584408
doi:

Substances chimiques

Oxygen S88TT14065

Banques de données

figshare
['10.6084/m9.figshare.20553234.v1']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0273402

Subventions

Organisme : Department of Health
Pays : United Kingdom

Déclaration de conflit d'intérêts

ASJC is an employee of Synoptic (funder). All other authors report no conflicts of interest.

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Auteurs

Nikhil Mayor (N)

Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom.

Harry Knights (H)

Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom.
University College London, London, United Kingdom.

Aleksandra Kotwica (A)

Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, United Kingdom.

Andrew Solomon Joseph Coppola (ASJ)

Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Harriet Hunter (H)

Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom.

Nathan Jeffreys (N)

Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom.

Alexander Morgan (A)

Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom.

Shivani Gupta (S)

Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom.

James Prentice (J)

Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom.

Rebecca Macfarlane (R)

Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom.

Emma Russell-Jones (E)

King's College London, London, United Kingdom.

Theodore Dassios (T)

King's College London, London, United Kingdom.

David Russell-Jones (D)

Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom.
University of Surrey, Guildford, United Kingdom.

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