Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort.

Correlation Dental Anomalies Dental Caries Multi-ethnic Multivariate GWAS

Journal

Frontiers in dental medicine
ISSN: 2673-4915
Titre abrégé: Front Dent Med
Pays: Switzerland
ID NLM: 101777956

Informations de publication

Date de publication:
2021
Historique:
entrez: 21 10 2022
pubmed: 1 1 2021
medline: 1 1 2021
Statut: ppublish

Résumé

Odontogenesis is a complex process, where disruption can result in dental anomalies and/or increase the risk of developing dental caries. Based on previous studies, certain dental anomalies tend to co-occur in patients, suggesting that these traits may share common genetic and etiological components. The main goal of this study was to implement a multivariate genome-wide association study approach to identify genetic variants shared between correlated structural dental anomalies and dental caries. Our cohort (

Identifiants

pubmed: 36267138
doi: 10.3389/fdmed.2021.771116
pmc: PMC9581442
mid: NIHMS1804022
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIDCR NIH HHS
ID : U01 DE024425
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE016930
Pays : United States
Organisme : NCBDD CDC HHS
ID : R01 DD000295
Pays : United States
Organisme : NIDCR NIH HHS
ID : R37 DE008559
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE011931
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE024571
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE016148
Pays : United States

Références

J Contemp Dent Pract. 2009 Jul 01;10(4):67-74
pubmed: 19575056
R Soc Open Sci. 2018 Jan 3;5(1):170761
pubmed: 29410800
Dev Dyn. 2011 Feb;240(2):432-40
pubmed: 21246660
J Neurosci. 2002 Jul 1;22(13):5473-80
pubmed: 12097499
J Dent Res. 2008 Jul;87(7):617-23
pubmed: 18573979
PLoS One. 2014 Apr 24;9(4):e95923
pubmed: 24763738
Swed Dent J Suppl. 1982;15:153-62
pubmed: 6963769
Hum Biol. 2017 Apr;89(2):157-169
pubmed: 29299963
Am J Med Genet A. 2014 Feb;164A(2):353-9
pubmed: 24449199
PLoS One. 2013 Aug 14;8(8):e72653
pubmed: 23967329
Curr Opin Cell Biol. 1996 Dec;8(6):844-50
pubmed: 8939666
J Dent Res. 2018 May;97(5):515-522
pubmed: 29364747
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4520-4
pubmed: 10781055
Trends Genet. 1995 Oct;11(10):405-11
pubmed: 7482767
Arch Oral Biol. 2009 Dec;54 Suppl 1:S79-85
pubmed: 19144325
Br J Orthod. 1999 Sep;26(3):195-203
pubmed: 10532158
Development. 2000 Jan;127(1):13-22
pubmed: 10654596
Gene Expr Patterns. 2005 Jun;5(5):609-17
pubmed: 15939373
BMC Oral Health. 2017 Mar 11;17(1):62
pubmed: 28284207
J Int Med Res. 2019 Apr;47(4):1696-1704
pubmed: 30803280
Int J Paediatr Dent. 2014 Jul;24(4):286-92
pubmed: 24237197
Mol Cell Biol. 2004 Jul;24(13):5733-45
pubmed: 15199130
Matrix Biol. 2014 Sep;38:48-58
pubmed: 25008349
Nat Rev Genet. 2010 Jul;11(7):459-63
pubmed: 20548291
Cleft Palate Craniofac J. 2011 Jan;48(1):103-8
pubmed: 20507240
BMC Dev Biol. 2013 Apr 08;13:11
pubmed: 23566240
Cells Tissues Organs. 2017;203(1):1-11
pubmed: 27627434
Genet Epidemiol. 2008 Apr;32(3):215-26
pubmed: 18161052
BMC Oral Health. 2014 Oct 16;14:125
pubmed: 25323952
Cleft Palate Craniofac J. 2000 Jul;37(4):395-405
pubmed: 10912719
Am J Hum Biol. 2006 Jul-Aug;18(4):540-55
pubmed: 16788889
BMC Oral Health. 2019 Jan 22;19(1):22
pubmed: 30670012
J Biol Chem. 2001 Nov 23;276(47):44163-72
pubmed: 11557747
J Hum Genet. 2013 Dec;58(12):799-803
pubmed: 24172245
Mech Dev. 2001 Sep;107(1-2):155-7
pubmed: 11520671
J Dent Res. 2008 May;87(5):435-9
pubmed: 18434572
Acta Histochem Cytochem. 2015 Apr 28;48(2):37-45
pubmed: 26175546
Orthod Craniofac Res. 2006 Feb;9(1):52-6
pubmed: 16420275
J Bone Miner Res. 2007 Aug;22(8):1234-44
pubmed: 17488195
Int J Dent. 2010;2010:649643
pubmed: 20339488
J Cell Sci. 2003 May 1;116(Pt 9):1647-8
pubmed: 12665545
Cleft Palate Craniofac J. 1996 Sep;33(5):436-9
pubmed: 8891376
PLoS One. 2013 Apr 08;8(4):e61231
pubmed: 23593441
Cleft Palate Craniofac J. 2001 Jul;38(4):374-8
pubmed: 11420017
J Dent Res. 2017 Sep;96(10):1106-1114
pubmed: 28535364
J Histochem Cytochem. 2003 Jan;51(1):41-54
pubmed: 12502753
Front Physiol. 2017 Jun 29;8:455
pubmed: 28706494
Nat Genet. 2000 Apr;24(4):391-5
pubmed: 10742104
Cell. 1996 Dec 13;87(6):1001-14
pubmed: 8978605
Eur J Med Genet. 2008 Jul-Aug;51(4):273-91
pubmed: 18499550
Crit Rev Oral Biol Med. 1998;9(2):179-200
pubmed: 9603235
J Periodontol. 2012 Nov;83(11):1407-19
pubmed: 22348697
J Dent Res. 2015 Jul;94(7):905-12
pubmed: 26082386
Bioinformatics. 2009 Jan 1;25(1):132-3
pubmed: 19019849
Dent Clin North Am. 2013 Apr;57(2):301-15
pubmed: 23570807
Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):544-60
pubmed: 24066766
Int J Dent. 2015;2015:938213
pubmed: 26106416
Sci Rep. 2015 May 08;5:9903
pubmed: 25952286
Cleft Palate Craniofac J. 2009 Sep;46(5):529-31
pubmed: 20050376
Genet Epidemiol. 2013 Jul;37(5):512-521
pubmed: 23650146
Appl Clin Genet. 2016 Nov 30;9:169-177
pubmed: 27942229
Cleft Palate Craniofac J. 2006 Nov;43(6):726-30
pubmed: 17105318
Am J Hum Genet. 2009 Nov;85(5):699-705
pubmed: 19853237

Auteurs

Rasha N Alotaibi (RN)

Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Brian J Howe (BJ)

Department of Family Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, USA.
The Iowa Center for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, USA.

Lina M Moreno Uribe (LM)

The Iowa Center for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA, USA.
Department of Orthodontics, School of Dentistry, University of Iowa, Iowa City, IA, USA.

Consuelo Valencia Ramirez (CV)

Clinica Noel, Medellin, Colombia.

Claudia Restrepo (C)

Clinica Noel, Medellin, Colombia.

Frederic W B Deleyiannis (FWB)

UCHealth Medical Group, Colorado Springs, CO, USA.

Carmencita Padilla (C)

Department of Pediatrics, College of Medicine, University of the Philippines, Manila.

Ieda M Orioli (IM)

Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Carmen J Buxó (CJ)

School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.

Jacqueline T Hecht (JT)

Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas, TX, USA.

George L Wehby (GL)

Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, USA.

Katherine Neiswanger (K)

Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Jeffery C Murray (JC)

Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.

John R Shaffer (JR)

Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Seth M Weinberg (SM)

Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Mary L Marazita (ML)

Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Classifications MeSH