Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide.

Akt Alzheimer’s disease amyloid β-peptide insulin insulin resistance

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2022
Historique:
received: 22 12 2021
revised: 22 07 2022
accepted: 23 09 2022
entrez: 21 10 2022
pubmed: 22 10 2022
medline: 22 10 2022
Statut: epublish

Résumé

Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first hallmarks of Type 2 diabetes). Regarding Alzheimer's disease, amyloid β-peptide aggregation into β-sheets is the main hallmark of Alzheimer's disease. At monomeric state, amyloid β-peptide is not toxic but its function in brain, if any, is unknown. Here we show, by

Identifiants

pubmed: 36267327
doi: 10.1093/braincomms/fcac243
pii: fcac243
pmc: PMC9576151
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcac243

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

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Auteurs

Rubén Molina-Fernández (R)

Laboratory of Structural Bioinformatics (GRIB), Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Pol Picón-Pagès (P)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Alejandro Barranco-Almohalla (A)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Giulia Crepin (G)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Víctor Herrera-Fernández (V)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Anna García-Elías (A)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Hugo Fanlo-Ucar (H)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Xavier Fernàndez-Busquets (X)

Barcelona Institute for Global Health (ISGlobal, Hospital Clínic-Universitat de Barcelona), 08036 Barcelona, Spain.
Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 08028 Barcelona, Spain.

Jordi García-Ojalvo (J)

Laboratory of Dynamical Systems Biology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Baldomero Oliva (B)

Laboratory of Structural Bioinformatics (GRIB), Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Francisco J Muñoz (FJ)

Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Classifications MeSH