Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice.


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
14 Oct 2022
Historique:
received: 24 05 2022
entrez: 21 10 2022
pubmed: 22 10 2022
medline: 22 10 2022
Statut: epublish

Résumé

Carboxylesterases are members of the serine hydrolase superfamily and metabolize drugs, pesticides, and lipids. Previous research showed that inhibition of carboxylesterase 1 (CES1) in human macrophages altered the immunomodulatory effects of lipid mediators called prostaglandin glyceryl esters, which are produced by cyclooxygenase-catalyzed oxygenation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Ces1d - the mouse ortholog of human CES1 - is the most abundant Ces isoform in murine lung tissues and alveolar macrophages and a major target of organophosphate poisons. Monoacylglycerol lipase (Magl) is also expressed in murine lung and is the main enzyme responsible for 2-AG catabolism. Several metabolic benefits are observed in Ces1d

Identifiants

pubmed: 36268116
doi: 10.1021/acsptsci.2c00098
pmc: PMC9578131
doi:

Types de publication

Journal Article

Langues

eng

Pagination

919-931

Subventions

Organisme : NIGMS NIH HHS
ID : R15 GM128206
Pays : United States
Organisme : NIH HHS
ID : T35 OD010432
Pays : United States

Informations de copyright

© 2022 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Brittany N Szafran (BN)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Abdolsamad Borazjani (A)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Hannah L Scheaffer (HL)

Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, College of Agriculture and Life Sciences, Mississippi State University, Mississippi State, Mississippi39762, United States.

J Allen Crow (JA)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Ann Marie McBride (AM)

Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Oluwabori Adekanye (O)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Caitlin B Wonnacott (CB)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Richard Lehner (R)

Departments of Cell Biology and Pediatrics, Group on Molecular & Cell Biology of Lipids, University of Alberta, Edmonton, ABT6G 2R3, Canada.

Barbara L F Kaplan (BLF)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Matthew K Ross (MK)

Department of Comparative Biomedical Sciences, Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi39762, United States.

Classifications MeSH