Vitamin D status can affect COVID-19 outcomes also in pediatric population.
, IFN-γ, reduce interferon-gamma
, RAS, renin-angiotensin system
ACE2, angiotensin-converting enzyme 2
CI, confidence interval
COVID-19
Children
DAMPs, damage-associated molecular patterns
DCs, dendritic cells
HR, Hazard Risk
ICU, intensive care unit
IL, interleukin
IgE, immunoglobulin E
Immunity
MD, mean difference
NK, natural killer
OR, odds ratio
PAMPs, pathogen-associated molecular patterns
PRRs, pattern recognition receptors
RCTs, randomized control trials
RR, risk ratio
SARS-CoV-2 infection
TLRs, Toll-like receptors
TNF-α, tumor necrosis factor-α
Treg cells, CD, regulatory T cellcluster of differentiation
VDRs, vitamin D receptors
Vitamin D
Journal
PharmaNutrition
ISSN: 2213-4344
Titre abrégé: PharmaNutrition
Pays: Netherlands
ID NLM: 101602522
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
03
05
2022
revised:
12
10
2022
accepted:
12
10
2022
pubmed:
22
10
2022
medline:
22
10
2022
entrez:
21
10
2022
Statut:
ppublish
Résumé
vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D's role in the pathophysiology of COVID-19 disease. the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population. further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.
Sections du résumé
Background
UNASSIGNED
vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D's role in the pathophysiology of COVID-19 disease.
Results
UNASSIGNED
the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population.
Conclusions
UNASSIGNED
further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.
Identifiants
pubmed: 36268528
doi: 10.1016/j.phanu.2022.100319
pii: S2213-4344(22)00032-9
pmc: PMC9562619
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100319Informations de copyright
© 2022 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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