Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation.
conjunctiva
cornea
epithelial plasticity
goblet cell metaplasia
limbal stem cell deficiency
limbus
ocular surface
squamous metaplasia
stem cells
transdifferentiation
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
08 11 2022
08 11 2022
Historique:
received:
22
04
2022
revised:
25
09
2022
accepted:
26
09
2022
pubmed:
22
10
2022
medline:
15
11
2022
entrez:
21
10
2022
Statut:
ppublish
Résumé
Maintaining corneal health and transparency are necessary pre-requisites for exquisite vision, a function ascribed to stem cells (SCs) nestled within the limbus. Perturbations to this site or depletion of its SCs results in limbal SC deficiency. While characterizing a murine model of this disease, we discovered unusual transformation phenomena on the corneal surface including goblet cell metaplasia (GCM), conjunctival transdifferentiation, and squamous metaplasia (SQM). GCM arose from K8
Identifiants
pubmed: 36270283
pii: S2213-6711(22)00460-X
doi: 10.1016/j.stemcr.2022.09.011
pmc: PMC9669409
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2451-2466Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interests The authors declare no competing interests.
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