Selective light-up of dimeric G-quadruplex forming aptamers for efficient VEGF

G-Quadruplexes Aptamers, Nucleotide / metabolism Vascular Endothelial Growth Factor A / metabolism
Aptamers Fluorescence light-up recognition G-quadruplex

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Jan 2023
Historique:
received: 06 09 2022
revised: 08 10 2022
accepted: 13 10 2022
pubmed: 22 10 2022
medline: 22 12 2022
entrez: 21 10 2022
Statut: ppublish

Résumé

To develop efficient anticancer theranostic systems, we studied the interaction between a cyanine dye, analogue of thiazole orange (named CyOH), and two G-quadruplex-forming aptamers, V7t1 and 3R02, recognizing the Vascular Endothelial Growth Factor 165 (VEGF

Identifiants

DOI: 10.1016/j.ijbiomac.2022.10.128 PMID: 36270405
pubmed: 36270405
pii: S0141-8130(22)02370-4
doi: 10.1016/j.ijbiomac.2022.10.128
pii:
doi:

Substances chimiques

Aptamers, Nucleotide 0
Vascular Endothelial Growth Factor A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

344-357

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest Daniela Montesarchio reports financial support was provided by Italian Association for Cancer Research. No other relationship or activity that may be interpreted as a conflict of interest by the reader.

Auteurs

Ettore Napolitano (E)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Claudia Riccardi (C)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Rosa Gaglione (R)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Angela Arciello (A)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Valentina Pirota (V)

Department of Chemistry, University of Pavia, 27100 Pavia, Italy.

Alice Triveri (A)

Department of Chemistry, University of Pavia, 27100 Pavia, Italy.

Filippo Doria (F)

Department of Chemistry, University of Pavia, 27100 Pavia, Italy.

Domenica Musumeci (D)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Daniela Montesarchio (D)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy. Electronic address: daniela.montesarchio@unina.it.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › G-quadruplexes › Selective light-up of dimeric G-quadruplex...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Aptamères nucléotidiques › Selective light-up of dimeric G-quadruplex...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Selective light-up of dimeric G-quadruplex...