Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients.
Journal
Clinical and translational science
ISSN: 1752-8062
Titre abrégé: Clin Transl Sci
Pays: United States
ID NLM: 101474067
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
23
07
2022
received:
06
04
2022
accepted:
17
08
2022
pubmed:
23
10
2022
medline:
16
12
2022
entrez:
22
10
2022
Statut:
ppublish
Résumé
This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the same individuals to address the clinical dilemma on preferred thiazide for hypertension (HTN) management. We included 15 African American (AA) and 35 European American (EA) patients with HTN treated with HCTZ and CTD as part of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and PEAR-2 trials, respectively. Mean reduction in systolic/diastolic blood pressure (SBP/DBP) with HCTZ versus CTD was 8/5 versus 16/8 mmHg among EA patients (p < 1.0e
Identifiants
pubmed: 36271676
doi: 10.1111/cts.13396
pmc: PMC9747127
doi:
Substances chimiques
Chlorthalidone
Q0MQD1073Q
Hydrochlorothiazide
0J48LPH2TH
Antihypertensive Agents
0
Thiazides
0
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2858-2867Subventions
Organisme : American Heart Association-American Stroke Association
ID : 20PRE35210065
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000135
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000454
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000064
Pays : United States
Organisme : NIH HHS
ID : U01-GM074492
Pays : United States
Informations de copyright
© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
Références
Hypertension. 2006 Mar;47(3):352-8
pubmed: 16432050
JAMA Intern Med. 2020 Apr 1;180(4):542-551
pubmed: 32065600
Circulation. 2012 Oct 23;126(17):2105-14
pubmed: 23091084
Hypertension. 2015 May;65(5):1041-6
pubmed: 25733245
Am J Med. 2012 Dec;125(12):1229.e1-1229.e10
pubmed: 22939358
Hypertension. 2016 Dec;68(6):1349-1354
pubmed: 27777360
JAMA. 2005 Apr 6;293(13):1595-608
pubmed: 15811979
Can J Cardiol. 2018 May;34(5):506-525
pubmed: 29731013
Physiol Res. 2016 Jul 18;65(3):461-8
pubmed: 27070747
Clin Transl Sci. 2022 Dec;15(12):2858-2867
pubmed: 36271676
Hypertension. 2009 Nov;54(5):951-3
pubmed: 19752290
Hypertension. 2011 Apr;57(4):665-6
pubmed: 21383308
Am Heart J. 2009 Mar;157(3):442-9
pubmed: 19249413
South Med J. 1995 Jan;88(1):42-6
pubmed: 7817226
JMIR Cardio. 2019 Mar 12;3(1):e13030
pubmed: 31758792
Hypertension. 2004 Jan;43(1):4-9
pubmed: 14638621
Clin Pharmacol Ther. 2014 Aug;96(2):175-81
pubmed: 24637943
Hypertension. 2019 Jul 1;:HYPERTENSIONAHA11912630
pubmed: 31256719
Am J Med. 2021 Jul;134(7):918-925.e2
pubmed: 33434556
Cardiol Rev. 2010 Jan-Feb;18(1):51-6
pubmed: 20010338
Endocr Connect. 2018 Apr;7(4):R135-R146
pubmed: 29540487
JAMA. 2002 Dec 18;288(23):2981-97
pubmed: 12479763
Hypertension. 2003 Dec;42(6):1206-52
pubmed: 14656957
Hypertension. 2020 Jun;75(6):1334-1357
pubmed: 32370572
Am J Hypertens. 2010 Sep;23(9):1014-22
pubmed: 20725057
Hypertension. 2018 Jun;71(6):e13-e115
pubmed: 29133356
Am J Hypertens. 2017 Oct 1;30(10):1008-1014
pubmed: 28531239
Ann Intern Med. 2013 Mar 19;158(6):447-55
pubmed: 23552325
J Gen Intern Med. 2017 Aug;32(8):921-930
pubmed: 28275946
Clin Transl Sci. 2019 Sep;12(5):497-504
pubmed: 31033190
J Clin Hypertens (Greenwich). 2000 Jul;2(4):253-257
pubmed: 11416657
Hypertension. 2012 Jun;59(6):1104-9
pubmed: 22547443
Am J Hypertens. 2018 Jan 12;31(2):133-135
pubmed: 29228096
Am J Hypertens. 2012 Mar;25(3):359-65
pubmed: 22089105
Lancet. 2003 Nov 8;362(9395):1527-35
pubmed: 14615107