Frequency of food allergy in Europe: An updated systematic review and meta-analysis.


Journal

Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028

Informations de publication

Date de publication:
02 2023
Historique:
revised: 14 10 2022
received: 15 07 2022
accepted: 18 10 2022
pubmed: 23 10 2022
medline: 1 2 2023
entrez: 22 10 2022
Statut: ppublish

Résumé

Food allergy (FA) is increasingly reported in Europe, however, the latest prevalence estimates were based on studies published a decade ago. The present work provides the most updated estimates of the prevalence and trends of FA in Europe. Databases were searched for studies published between 2012 and 2021, added to studies published up to 2012. In total, 110 studies were included in this update. Most studies were graded as moderate risk of bias. Pooled lifetime and point prevalence of self-reported FA were 19.9% (95% CI 16.6-23.3) and 13.1% (95% CI 11.3-14.8), respectively. The point prevalence of sensitization based on specific IgE (slgE) was 16.6% (95% CI 12.3-20.8), skin prick test (SPT) 5.7% (95% CI 3.9-7.4), and positive food challenge 0.8% (95% CI 0.5-0.9). While lifetime prevalence of self-reported FA and food challenge positivity only slightly changed, the point prevalence of self-reported FA, sIgE and SPT positivity increased from previous estimates. This may reflect a real increase, increased awareness, increased number of foods assessed, or increased number of studies from countries with less data in the first review. Future studies require rigorous designs and implementation of standardized methodology in diagnosing FA, including use of double-blinded placebo-controlled food challenge to minimize potential biases.

Identifiants

pubmed: 36271775
doi: 10.1111/all.15560
pmc: PMC10099188
doi:

Substances chimiques

Immunoglobulin E 37341-29-0
Allergens 0

Types de publication

Meta-Analysis Systematic Review Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

351-368

Informations de copyright

© 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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Auteurs

Giulia C I Spolidoro (GCI)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Yohannes Tesfaye Amera (YT)

School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Mohamed Mustafa Ali (MM)

School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Sungkutu Nyassi (S)

Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden.

Daniil Lisik (D)

Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden.

Athina Ioannidou (A)

Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden.

Graciela Rovner (G)

ACT Institutet Sweden, Gothenburg, Sweden.
Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Ekaterina Khaleva (E)

Faculty of Medicine, University of Southampton, Southampton, UK.

Carina Venter (C)

Section of Allergy and Immunology, School of Medicine, University of Colorado Denver, Children's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

Ronald van Ree (R)

Department of Experimental Immunology and Department of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Margitta Worm (M)

Division of Allergy and Immunology, Department of Dermatology, Allergy and Venerology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Berber Vlieg-Boerstra (B)

Department of Pediatrics, OLVG Hospital, Amsterdam, the Netherlands.
Department of Pediatrics, Rijnstate Hospital, Arnhem, the Netherlands.

Aziz Sheikh (A)

Usher Institute, University of Edinburgh, Edinburgh, UK.

Antonella Muraro (A)

Department of Mother and Child Health, The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, University of Padua, Padua, Italy.

Graham Roberts (G)

Faculty of Medicine, University of Southampton, Southampton, UK.
David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK.

Bright I Nwaru (BI)

Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden.
Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.

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