Starting a new chapter on class Ia ribonucleotide reductases.

Humans Ribonucleotide Reductases / chemistry Escherichia coli / genetics

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 01 04 2022
revised: 13 09 2022
accepted: 16 09 2022
pubmed: 23 10 2022
medline: 15 12 2022
entrez: 22 10 2022
Statut: ppublish

Résumé

Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found in Escherichia coli, eukaryotes including humans, and many pathogenic and nonpathogenic prokaryotes. This review covers recent advances in our understanding of class Ia RNRs, including a recent reporting of a structure of the active state of the E. coli enzyme and the impacts that the structure has had on spurring research into the mechanism of long-range radical transfer. Additionally, the review considers other recent structural and biochemical research on class Ia RNRs and the potential of that work for the development of anticancer and antibiotic therapeutics.

Identifiants

DOI: 10.1016/j.sbi.2022.102489 PMID: 36272229
pubmed: 36272229
pii: S0959-440X(22)00168-3
doi: 10.1016/j.sbi.2022.102489
pii:
doi:

Substances chimiques

Ribonucleotide Reductases EC 1.17.4.-

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102489

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Talya S Levitz (TS)

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: https://twitter.com/@TalyaLevitz.

Catherine L Drennan (CL)

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: cdrennan@mit.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Starting a new chapter on class Ia...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Ribonucleotide reductases › Starting a new chapter on class Ia...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Starting a new chapter on class Ia...