Mantuoluosides A-H, new steroids isolated from the leaves of Datura stramonium L.
Anti-inflammatory
Datura stramonium L.
Steroids
Withanolides
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
16
09
2022
revised:
15
10
2022
accepted:
15
10
2022
pubmed:
23
10
2022
medline:
7
12
2022
entrez:
22
10
2022
Statut:
ppublish
Résumé
Eight new steroids, designated mantuoluosides A-H (1-8), were obtained from the enrichment of steroids of the Datura stramonium L. using HPD-BJQH macroporous resin. Their respective structures were elucidated based on spectroscopic methods and comparison data with literature. The anti-inflammatory activities of these compounds were evaluated on (LPS)-induced RAW264.7 cells with inhibition ratio. It was found that most isolates showed potential anti-inflammatory activity with varying degrees of inhibition rate in a concentration-dependent manner at non-cytotoxic concentrations.
Identifiants
pubmed: 36272704
pii: S0367-326X(22)00217-9
doi: 10.1016/j.fitote.2022.105339
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Steroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105339Informations de copyright
Copyright © 2022. Published by Elsevier B.V.