Chloride-sensitive signaling turns the potassium switch on.

Mice Animals Potassium / metabolism Chlorides / metabolism Protein Serine-Threonine Kinases / genetics Sodium Chloride Symporters / metabolism Sodium / metabolism Solute Carrier Family 12, Member 3 / metabolism

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
11 2022
Historique:
received: 17 07 2022
revised: 16 08 2022
accepted: 19 08 2022
entrez: 22 10 2022
pubmed: 23 10 2022
medline: 26 10 2022
Statut: ppublish

Résumé

The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation.

Identifiants

DOI: 10.1016/j.kint.2022.08.023 PMID: 36272750
pubmed: 36272750
pii: S0085-2538(22)00699-8
doi: 10.1016/j.kint.2022.08.023
pii:
doi:

Substances chimiques

Potassium RWP5GA015D
Chlorides 0
Protein Serine-Threonine Kinases EC 2.7.11.1
Sodium Chloride Symporters 0
Sodium 9NEZ333N27
Solute Carrier Family 12, Member 3 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

956-958

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Ewout J Hoorn (EJ)

Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, the Netherlands. Electronic address: e.j.hoorn@erasmusmc.nl.

Jeroen H F de Baaij (JHF)

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Eucaryotes › Animaux › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Potassium › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Symporteurs des ions sodium-chlorure › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Chloride-sensitive signaling turns the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Symporteurs des ions sodium-potassium-chlorure › Membre-3 de la famille-12 des transporteurs de solutés › Chloride-sensitive signaling turns the...