Zoning in on podocytes.

Humans Podocytes Kidney Glomerulus Kidney Diseases Hypertension

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
11 2022
Historique:
received: 16 08 2022
accepted: 25 08 2022
entrez: 22 10 2022
pubmed: 23 10 2022
medline: 26 10 2022
Statut: ppublish

Résumé

Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary glomeruli are not only morphologically heterogeneous per se, but respond differently to stressors, such as age and hypertension. This suggests that zonal glomerular changes harbor critical information to understand glomerulopathies.

Identifiants

DOI: 10.1016/j.kint.2022.08.030 PMID: 36272754
pubmed: 36272754
pii: S0085-2538(22)00727-X
doi: 10.1016/j.kint.2022.08.030
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

966-968

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK056799
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097598
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Auteurs

Stuart J Shankland (SJ)

Division of Nephrology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA. Electronic address: stuartjs@uw.edu.

Oliver Wessely (O)

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA. Electronic address: wesselo@ccf.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Zoning in on podocytes.
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › Zoning in on podocytes.
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Glomérule rénal › Zoning in on podocytes.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Zoning in on podocytes.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Zoning in on podocytes.