Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

Humans Genetic Predisposition to Disease Genome-Wide Association Study Risk Factors Lymphoma, Non-Hodgkin / genetics Germ Cells Case-Control Studies Polymorphism, Single Nucleotide

Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
12 2022
Historique:
received: 21 03 2022
accepted: 15 09 2022
revised: 22 05 2022
pubmed: 24 10 2022
medline: 3 12 2022
entrez: 23 10 2022
Statut: ppublish

Résumé

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10

Identifiants

DOI: 10.1038/s41375-022-01711-0 PMID: 36273105 PMC: PMC10337695
pubmed: 36273105
doi: 10.1038/s41375-022-01711-0
pii: 10.1038/s41375-022-01711-0
pmc: PMC10337695
mid: NIHMS1841845
doi:

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2835-2844

Subventions

Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA148690
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA134919
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097274
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134674
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12014/3
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA118444
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098122
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010136
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA049449
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA149445
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Auteurs

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA. berndts@mail.nih.gov.
ORCID: 0000-0001-5230-0652

Joseph Vijai (J)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Yolanda Benavente (Y)

Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Nicola J Camp (NJ)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
ORCID: 0000-0002-4788-1998

Alexandra Nieters (A)

Institute for Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.

Zhaoming Wang (Z)

Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
ORCID: 0000-0001-7556-3869

Karin E Smedby (KE)

Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Hematology Center, Karolinska University Hospital, Stockholm, Sweden.

Geffen Kleinstern (G)

School of Public Health, University of Haifa, Haifa, Israel.

Henrik Hjalgrim (H)

Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Department of Haematology, Rigshospitalet, Copenhagen, Denmark.
Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
ORCID: 0000-0002-4436-6798

Caroline Besson (C)

Centre Hospitalier de Versailles, Le Chesnay, France.
Université Paris-Saclay, UVSQ, Inserm, Équipe "Exposome et Hérédité", CESP, Villejuif, France.
ORCID: 0000-0003-4364-7173

Christine F Skibola (CF)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.

Lindsay M Morton (LM)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
ORCID: 0000-0001-9767-2310

Angela R Brooks-Wilson (AR)

Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Lauren R Teras (LR)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.
ORCID: 0000-0003-2419-8536

Charles Breeze (C)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Joshua Arias (J)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
ORCID: 0000-0001-6545-6656

Hans-Olov Adami (HO)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Institute of Health and Society, Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway.
ORCID: 0000-0001-9592-5791

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Kenneth C Anderson (KC)

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6418-0886

Stephen M Ansell (SM)

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0003-1244-6758

Bryan Bassig (B)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Nikolaus Becker (N)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.

Parveen Bhatti (P)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Brenda M Birmann (BM)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-7550-5498

Paolo Boffetta (P)

Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, 11794, NY, USA.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, 41026, Italy.

Paige M Bracci (PM)

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Paul Brennan (P)

International Agency for Research on Cancer (IARC), Lyon, France.

Elizabeth E Brown (EE)

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.

Laurie Burdett (L)

Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA.

Lisa A Cannon-Albright (LA)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.

Ellen T Chang (ET)

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Center for Health Sciences, Exponent, Inc., Menlo Park, CA, USA.

Brian C H Chiu (BCH)

Department of Public Health Sciences University of Chicago, Chicago, IL, USA.
ORCID: 0000-0001-8979-7244

Charles C Chung (CC)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Jacqueline Clavel (J)

CRESS, UMR1153, INSERM, Villejuif, France.
Université de Paris-Cité, Villejuif, France.

Pierluigi Cocco (P)

Centre for Occupational and Environmental Health, Division of Population Science, Health Services Research & Primary Care, University of Manchester, Manchester, United Kingdom.

Graham Colditz (G)

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-7307-0291

Lucia Conde (L)

Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, United Kingdom.

David V Conti (DV)

Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

David G Cox (DG)

INSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France.

Karen Curtin (K)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Delphine Casabonne (D)

Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Immaculata De Vivo (I)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Arjan Diepstra (A)

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

W Ryan Diver (WR)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.
ORCID: 0000-0002-5418-9000

Ahmet Dogan (A)

Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-6576-5256

Christopher K Edlund (CK)

Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Lenka Foretova (L)

Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Joseph F Fraumeni (JF)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Attilio Gabbas (A)

Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari, Italy.

Hervé Ghesquières (H)

Department of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre Benite, France.
CIRI, Centre International de Recherche en Infectiologie, Team Lymphoma Immuno-Biology, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia.
ORCID: 0000-0003-4946-9099

Sally Glaser (S)

Cancer Prevention Institute of California, Fremont, CA, USA.
Stanford Cancer Institute, Stanford, CA, USA.

Martha Glenn (M)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Bengt Glimelius (B)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Jian Gu (J)

Department of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA.
ORCID: 0000-0003-3499-0973

Thomas M Habermann (TM)

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Christopher A Haiman (CA)

Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Corinne Haioun (C)

Lymphoid Malignancies Unit, Henri Mondor Hospital and University Paris Est, Créteil, France.

Jonathan N Hofmann (JN)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
ORCID: 0000-0002-1043-5812

Theodore R Holford (TR)

Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.

Elizabeth A Holly (EA)

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Amy Hutchinson (A)

Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA.

Aalin Izhar (A)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Rebecca D Jackson (RD)

Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, USA.

Ruth F Jarrett (RF)

MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
ORCID: 0000-0003-0390-3478

Rudolph Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.

Eleanor Kane (E)

Department of Health Sciences, University of York, York, United Kingdom.
ORCID: 0000-0002-7438-9982

Laurence N Kolonel (LN)

Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Yinfei Kong (Y)

Information Systems and Decision Sciences, California State University, Fullerton, Fullerton, CA, USA.

Peter Kraft (P)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Anne Kricker (A)

Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.

Annette Lake (A)

MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.

Qing Lan (Q)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Charles Lawrence (C)

Westat, Rockville, MA, USA.

Dalin Li (D)

F. Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Mark Liebow (M)

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Brian K Link (BK)

Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.

Corrado Magnani (C)

CPO-Piemonte and Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Marc Maynadie (M)

INSERM U1231, EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, France.

James McKay (J)

International Agency for Research on Cancer (IARC), Lyon, France.

Mads Melbye (M)

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Jebsen Center for Genetic epidemiology, NTNU, Trondheim, Norway.
Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Genetics, Stanford University Medical School, Stanford, CA, USA.
ORCID: 0000-0001-8264-6785

Lucia Miligi (L)

Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia.
ORCID: 0000-0001-5764-7268

Thierry J Molina (TJ)

Department of Pathology, APHP, Necker and Robert Debré, Université Paris Cité, Institut Imagine, INSERM U1163, Paris, France.

Alain Monnereau (A)

CRESS, UMR1153, INSERM, Villejuif, France.
Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux, Cedex, France.

Rebecca Montalvan (R)

Westat, Rockville, MA, USA.

Kari E North (KE)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Anne J Novak (AJ)

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-7904-1651

Kenan Onel (K)

Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Hempstead, New York, NY, USA.

Mark P Purdue (MP)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Kristin A Rand (KA)

Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Elio Riboli (E)

School of Public Health, Imperial College London, London, United Kingdom.

Jacques Riby (J)

Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA, USA.

Eve Roman (E)

Department of Health Sciences, University of York, York, United Kingdom.

Gilles Salles (G)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-9541-8666

Douglas W Sborov (DW)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Richard K Severson (RK)

Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, USA.

Tait D Shanafelt (TD)

Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Martyn T Smith (MT)

Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, CA, USA.

Alexandra Smith (A)

Department of Health Sciences, University of York, York, United Kingdom.

Kevin W Song (KW)

Leukemia/Bone Marrow Transplantation Program, BC Cancer Agency, Vancouver, BC, Canada.
Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Lei Song (L)

Center for Cancer Research, National Cancer Institute, Frederick, MA, USA.

Melissa C Southey (MC)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VC, Australia.
Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, VC, 3010, Australia.

John J Spinelli (JJ)

Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Anthony Staines (A)

School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.

Deborah Stephens (D)

Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.

Heather J Sutherland (HJ)

Leukemia/Bone Marrow Transplantation Program, BC Cancer Agency, Vancouver, BC, Canada.
Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Kaitlyn Tkachuk (K)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Carrie A Thompson (CA)

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Hervé Tilly (H)

Centre Henri Becquerel, Université de Rouen, Rouen, France.

Lesley F Tinker (LF)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Ruth C Travis (RC)

Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.

Jenny Turner (J)

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, NSW, Australia.

Celine M Vachon (CM)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-1962-9322

Claire M Vajdic (CM)

The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
ORCID: 0000-0002-3612-8298

Anke Van Den Berg (A)

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-8894-2638

David J Van Den Berg (DJ)

Department of Population and Public Health Sciences, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Roel C H Vermeulen (RCH)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Paolo Vineis (P)

MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
Human Genetics Foundation, Turin, Italy.

Sophia S Wang (SS)

Division of Health Analytics, City of Hope Beckman Research Institute, Duarte, CA, USA.

Elisabete Weiderpass (E)

International Agency for Research on Cancer (IARC), Lyon, France.
ORCID: 0000-0003-2237-0128

George J Weiner (GJ)

Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.

Stephanie Weinstein (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
ORCID: 0000-0002-3834-1535

Nicole Wong Doo (NW)

Concord Clinical School, University of Sydney, Concord, NSW, Australia.

Yuanqing Ye (Y)

Department of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA.

Meredith Yeager (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MA, USA.
ORCID: 0000-0003-3871-2225

Kai Yu (K)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Anne Zeleniuch-Jacquotte (A)

Department of Population Health, New York University School of Medicine, New York, NY, USA.
Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, USA.

Yawei Zhang (Y)

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.

Tongzhang Zheng (T)

Department of Epidemiology, Brown University, Providence, RI, USA.

Elad Ziv (E)

Division of General Internal Medicine, Department of Medicine, Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.

Joshua Sampson (J)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

Nilanjan Chatterjee (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA, USA.
Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MA, USA.

Kenneth Offit (K)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Wendy Cozen (W)

Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.

Xifeng Wu (X)

Department of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA.

James R Cerhan (JR)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-7482-178X

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.
ORCID: 0000-0002-2324-3393

Susan L Slager (SL)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-5173-4712

Nathaniel Rothman (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Distinct germline genetic susceptibility...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Distinct germline genetic susceptibility...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Distinct germline genetic susceptibility...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Distinct germline genetic susceptibility...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Distinct germline genetic susceptibility...
questionsmedicales.fr › Cellules › Cellules germinales › Distinct germline genetic susceptibility...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Distinct germline genetic susceptibility...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Distinct germline genetic susceptibility...