Intermittent Hypoxia Differentially Regulates Adenosine Receptors in Phrenic Motor Neurons with Spinal Cord Injury.

Rats Animals Motor Neurons Receptors, Purinergic P1 Spinal Cord Injuries Hypoxia Adenosine Sleep Apnea Syndromes
Adenosine receptors Cervical spinal cord injury Intermittent hypoxia Sleep apnea

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 12 2022
Historique:
received: 28 06 2022
revised: 04 10 2022
accepted: 07 10 2022
pubmed: 24 10 2022
medline: 15 12 2022
entrez: 23 10 2022
Statut: ppublish

Résumé

Cervical spinal cord injury (cSCI) impairs neural drive to the respiratory muscles, causing life- threatening complications such as respiratory insufficiency and diminished airway protection. Repetitive "low dose" acute intermittent hypoxia (AIH) is a promising strategy to restore motor function in people with chronic SCI. Conversely, "high dose" chronic intermittent hypoxia (CIH; ∼8 h/night), such as experienced during sleep apnea, causes pathology. Sleep apnea, spinal ischemia, hypoxia and neuroinflammation associated with cSCI increase extracellular adenosine concentrations and activate spinal adenosine receptors which in turn constrains the functional benefits of therapeutic AIH. Adenosine 1 and 2A receptors (A

Identifiants

DOI: 10.1016/j.neuroscience.2022.10.007 PMID: 36273657
pubmed: 36273657
pii: S0306-4522(22)00515-2
doi: 10.1016/j.neuroscience.2022.10.007
pii:
doi:

Substances chimiques

Receptors, Purinergic P1 0
Adenosine K72T3FS567

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

38-50

Subventions

Organisme : NIH HHS
ID : OT2 OD023854
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148030
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147554
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD055929
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD043730
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS119862
Pays : United States

Informations de copyright

Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

Auteurs

Yasin B Seven (YB)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Latoya L Allen (LL)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Marissa C Ciesla (MC)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Kristin N Smith (KN)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Amanda Zwick (A)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Alec K Simon (AK)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Ashley E Holland (AE)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Juliet V Santiago (JV)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Kelsey Stefan (K)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Ashley Ross (A)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Elisa J Gonzalez-Rothi (EJ)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

Gordon S Mitchell (GS)

Breathing Research and Therapeutics Center, Department of Physical Therapy and, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA. Electronic address: gsmitche@ufl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Intermittent Hypoxia Differentially Regulates...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Intermittent Hypoxia Differentially Regulates...