Some things old, new and borrowed: Delivery of dabrafenib and vemurafenib to melanoma cells via self-assembled nanomicelles based on an amphiphilic dendrimer.

Humans Vemurafenib Micelles Scattering, Small Angle X-Ray Diffraction Melanoma / drug therapy
Amphiphilic dendrimer BRAF inhibitors Drug delivery Melanoma Self-assembled nanomicelles

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Jan 2023
Historique:
received: 08 07 2022
revised: 19 10 2022
accepted: 19 10 2022
pubmed: 24 10 2022
medline: 15 12 2022
entrez: 23 10 2022
Statut: ppublish

Résumé

Two clinically approved anticancer drugs targeting BRAF in melanoma patients - dabrafenib (DAB) and vemurafenib (VEM) - have been successfully encapsulated into nanomicelles formed upon self-assembly of an amphiphilic dendrimer AD based on two C

Identifiants

DOI: 10.1016/j.ejps.2022.106311 PMID: 36273785
pubmed: 36273785
pii: S0928-0987(22)00196-8
doi: 10.1016/j.ejps.2022.106311
pii:
doi:

Substances chimiques

Vemurafenib 207SMY3FQT
Micelles 0
dabrafenib QGP4HA4G1B

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106311

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Maria Russi (M)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) - DEA, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy.

Rachele Valeri (R)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) - DEA, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy.

Domenico Marson (D)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) - DEA, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy.

Chiara Danielli (C)

Department of Chemical and Pharmaceutical Sciences, DSCF, University of Trieste, Via Giorgeri 1, Trieste 34127, Italy.

Fulvia Felluga (F)

Department of Chemical and Pharmaceutical Sciences, DSCF, University of Trieste, Via Giorgeri 1, Trieste 34127, Italy.

Aura Tintaru (A)

Aix Marseille Univ, CNRS - Centre Interdisciplinaire de Nanosciences de Marseille (CINaM) UMR 7325 - Département IMMF - Campus Luminy, 163, Avenue de Luminy, Marseille 13288, France.

Natasa Skoko (N)

Biotechnology Development Unit, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

Suzana Aulic (S)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) - DEA, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy; Biotechnology Development Unit, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

Erik Laurini (E)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) - DEA, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy. Electronic address: erik.laurini@dia.units.it.

Sabrina Pricl (S)

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) - DEA, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy; Department of General Biophysics, University of Łódź, ul. Pomorska 141/143, Łódź 90-236, Poland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Some things old, new and borrowed: Delivery of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Vémurafénib › Some things old, new and borrowed: Delivery of...
questionsmedicales.fr › Préparations pharmaceutiques › Micelles › Some things old, new and borrowed: Delivery of...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Diffusion aux petits angles › Some things old, new and borrowed: Delivery of...
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › Some things old, new and borrowed: Delivery of...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Some things old, new and borrowed: Delivery of...