Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
12 Sep 2022
12 Sep 2022
Historique:
received:
21
07
2022
accepted:
06
09
2022
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
Promoting a senescent phenotype to suppress tumour progression may present an alternative strategy for treating cancer and encourages the development of positron emission tomography (PET) imaging biomarkers for assessing response to treatment. The accumulation of lipofuscin deposits in senescent cells is visualised using the pathology stain Sudan Black B (SBB) which is an emerging biomarker of senescence. We describe the design, synthesis and evaluation of [
Identifiants
pubmed: 36275107
doi: 10.1039/d2ra04535d
pii: d2ra04535d
pmc: PMC9475417
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26372-26381Subventions
Organisme : Medical Research Council
ID : MR/N020782/1
Pays : United Kingdom
Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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