Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model.
Bet v 1
aluminum
elastin-like polypeptide
hypo-allergenic
mouse model
nanoparticles
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
07
2022
accepted:
07
09
2022
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
26
10
2022
Statut:
epublish
Résumé
There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied micellar elastin-like polypeptides (ELPs), a type of self-assembling protein, to replace alum as vaccine adjuvant in birch pollen SCIT. ELP and an ELP-Bet v 1 fusion protein were expressed in
Identifiants
pubmed: 36275650
doi: 10.3389/fimmu.2022.1006776
pmc: PMC9583423
doi:
Substances chimiques
aluminum sulfate
34S289N54E
Antigens, Plant
0
Immunoglobulin E
37341-29-0
Elastin
9007-58-3
Micelles
0
Aluminum
CPD4NFA903
Salts
0
Allergens
0
Immunoglobulin G
0
Peptides
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1006776Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114839
Pays : United States
Informations de copyright
Copyright © 2022 van Strien, Warmenhoven, Logiantara, Makurat, Aglas, Bethanis, Leboux, van Rijt, MacKay, van Schijndel, Schneider, Olsthoorn, Jiskoot, van Ree and Kros.
Déclaration de conflit d'intérêts
HW is and JWS was an employee of HAL Allergy BV. JWS is an employee of SeraNovo BV. RR is a consultant for HAL Allergy BV, Citeq BV, Reacta Healthcare Ltd., Angany Inc., Mission MightyMe and AB Enzymes GmbH. RR reports speaker fees from HAL Allergy BV, ThermoFisher Scientific and ALK and has stock options of Angany Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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