Cardiovascular deconditioning and impact of artificial gravity during 60-day head-down bed rest-Insights from 4D flow cardiac MRI.
4D flow
artificial gravity
bed rest
cardiac MRI
cardiovascular deconditioning
microgravity
pulse wave velocity
wall shear stress
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
05
2022
accepted:
13
09
2022
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
Microgravity has deleterious effects on the cardiovascular system. We evaluated some parameters of blood flow and vascular stiffness during 60 days of simulated microgravity in head-down tilt (HDT) bed rest. We also tested the hypothesis that daily exposure to 30 min of artificial gravity (1 g) would mitigate these adaptations. 24 healthy subjects (8 women) were evenly distributed in three groups: continuous artificial gravity, intermittent artificial gravity, or control. 4D flow cardiac MRI was acquired in horizontal position before (-9 days), during (5, 21, and 56 days), and after (+4 days) the HDT period. The false discovery rate was set at 0.05. The results are presented as median (first quartile; third quartile). No group or group × time differences were observed so the groups were combined. At the end of the HDT phase, we reported a decrease in the stroke volume allocated to the lower body (-30% [-35%; -22%]) and the upper body (-20% [-30%; +11%]), but in different proportions, reflected by an increased share of blood flow towards the upper body. The aortic pulse wave velocity increased (+16% [+9%; +25%]), and so did other markers of arterial stiffness (
Identifiants
pubmed: 36277205
doi: 10.3389/fphys.2022.944587
pii: 944587
pmc: PMC9586290
doi:
Types de publication
Journal Article
Langues
eng
Pagination
944587Informations de copyright
Copyright © 2022 Rabineau, Issertine, Hoffmann, Gerlach, Caiani, Haut, van de Borne, Tank and Migeotte.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Stroke. 2004 Feb;35(2):464-8
pubmed: 14726547
J Magn Reson Imaging. 2012 May;35(5):1162-8
pubmed: 22271330
J Magn Reson Imaging. 2022 Jan;55(1):211-222
pubmed: 34173297
Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H668-76
pubmed: 16603687
J Appl Physiol (1985). 2010 Apr;108(4):838-44
pubmed: 20133438
Eur J Appl Physiol. 2011 Sep;111(9):2315-25
pubmed: 21336952
Exp Physiol. 2022 Mar;107(3):213-221
pubmed: 34921742
J Biomech Eng. 2021 Apr 1;143(4):
pubmed: 33156343
J Cardiovasc Magn Reson. 2022 Mar 18;24(1):18
pubmed: 35303893
Aviat Space Environ Med. 1995 Oct;66(10):982-91
pubmed: 8526836
NPJ Microgravity. 2022 Jul 12;8(1):25
pubmed: 35821029
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A54-A67
pubmed: 26630196
J Appl Physiol (1985). 2001 Nov;91(5):2374-83
pubmed: 11641383
Eur J Appl Physiol. 2009 May;106(2):217-27
pubmed: 19247686
J Atheroscler Thromb. 2019 Jul 1;26(7):603-615
pubmed: 31068504
ESC Heart Fail. 2021 Feb;8(1):729-744
pubmed: 33191629
J Atheroscler Thromb. 2006 Apr;13(2):101-7
pubmed: 16733298
Hypertension. 2010 Aug;56(2):240-6
pubmed: 20530294
Sci Rep. 2017 May 17;7(1):2007
pubmed: 28515420
J Appl Physiol (1985). 2002 Feb;92(2):586-94
pubmed: 11796668
Magn Reson Med. 2008 Nov;60(5):1218-31
pubmed: 18956416
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):
pubmed: 35022244
Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2230-9
pubmed: 11299226
Thromb Res. 2000 Dec 1;100(5):409-12
pubmed: 11150583
PLoS One. 2017 Jul 27;12(7):e0181381
pubmed: 28749968
J Appl Physiol (1985). 1997 Dec;83(6):2139-45
pubmed: 9390992
J Am Soc Echocardiogr. 2008 Feb;21(2):123-8
pubmed: 17686611
Sci Rep. 2020 Oct 19;10(1):17694
pubmed: 33077727
J Appl Physiol (1985). 2004 Sep;97(3):1022-31
pubmed: 15121745
J Hypertens. 2017 Jan;35(1):98-104
pubmed: 27906838
Acta Astronaut. 2005 Jul-Oct;57(2-8):75-80
pubmed: 16010754
Clin Physiol. 2000 Nov;20(6):496-504
pubmed: 11100398
PLoS One. 2011;6(5):e19775
pubmed: 21611118
J Appl Physiol (1985). 2014 Sep 15;117(6):624-32
pubmed: 25080927
J Appl Physiol (1985). 2020 Jul 1;129(1):108-123
pubmed: 32525433
Front Physiol. 2018 Nov 19;9:1553
pubmed: 30510516
Front Physiol. 2020 Sep 11;11:562377
pubmed: 33041861
PLoS One. 2020 Sep 18;15(9):e0239228
pubmed: 32946482
Acad Radiol. 2013 Jun;20(6):699-704
pubmed: 23510798
Cardiol Rev. 2019 May/Jun;27(3):122-126
pubmed: 30365406
Eur J Appl Physiol. 2000 Mar;81(5):384-90
pubmed: 10751099
Neurosci Lett. 2000 Mar 3;281(1):21-4
pubmed: 10686406
J Magn Reson Imaging. 2020 Oct;52(4):971-977
pubmed: 32374422
J Appl Physiol (1985). 2000 Sep;89(3):1046-54
pubmed: 10956349
J Appl Physiol (1985). 2011 Dec;111(6):1836-45
pubmed: 21737819
J Appl Physiol (1985). 2003 Jul;95(1):207-18
pubmed: 12794097
Aviat Space Environ Med. 1996 Nov;67(11):1069-79
pubmed: 8908346
J Appl Physiol (1985). 2015 Jan 1;118(1):29-35
pubmed: 25342708
MAGMA. 2018 Oct;31(5):653-663
pubmed: 29804208
J Magn Reson Imaging. 2014 Mar;39(3):550-8
pubmed: 24123545
J Appl Physiol (1985). 1992 Aug;73(2 Suppl):94S-100S
pubmed: 1526957
J Appl Physiol (1985). 2001 Sep;91(3):1207-13
pubmed: 11509517
Front Physiol. 2022 Jan 27;12:808999
pubmed: 35153816
Eur J Appl Physiol. 2013 Sep;113(9):2183-92
pubmed: 23079865
Cardiovasc Eng Technol. 2015 Mar;6(1):49-58
pubmed: 26577102
Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1174-H1181
pubmed: 30028202
J Appl Physiol (1985). 2007 Dec;103(6):1964-72
pubmed: 17947505
Cardiovasc Diagn Ther. 2014 Apr;4(2):173-92
pubmed: 24834414
Front Physiol. 2020 Aug 20;11:952
pubmed: 32973543
Eur J Appl Physiol. 2015 Sep;115(9):1975-83
pubmed: 25957107
J Investig Med. 2006 Sep;54(6):321-6
pubmed: 17134615
J Clin Endocrinol Metab. 2001 Nov;86(11):5389-95
pubmed: 11701712
Eur J Appl Physiol. 2021 Jul;121(7):2015-2026
pubmed: 33811556
J Gravit Physiol. 1997 Oct;4(3):61-5
pubmed: 11541871
PLoS One. 2016 Sep 26;11(9):e0163316
pubmed: 27669568
Acta Astronaut. 2001 Aug-Nov;49(3-10):227-35
pubmed: 11669112
Acta Astronaut. 2001 Aug-Nov;49(3-10):215-26
pubmed: 11669111
J Appl Physiol (1985). 2007 Mar;102(3):853-8
pubmed: 17082368
J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27
pubmed: 20338492
Front Physiol. 2019 May 22;10:581
pubmed: 31191330
J Appl Physiol (1985). 2007 Mar;102(3):836
pubmed: 17170201
Med Sci Monit. 2010 Dec;16(12):CR575-83
pubmed: 21119574
Ross Fiziol Zh Im I M Sechenova. 2007 Mar;93(3):300-5
pubmed: 17598473
J Hypertens. 2021 Nov 1;39(11):2128-2138
pubmed: 34269333
Front Physiol. 2021 May 28;12:685473
pubmed: 34122149
Magn Reson Med Sci. 2022 Mar 1;21(2):354-364
pubmed: 35185062
Int J Cardiol Hypertens. 2019 Jun 19;2:100013
pubmed: 33447746
Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H628-38
pubmed: 26747504
PLoS One. 2020 Jun 11;15(6):e0234361
pubmed: 32525946
Circulation. 2001 Apr 10;103(14):1851-7
pubmed: 11294802
Maturitas. 2007 Sep 20;58(1):70-4
pubmed: 17689895
Eur J Appl Physiol. 2012 Feb;112(2):605-16
pubmed: 21626041
J Appl Physiol (1985). 2007 Jul;103(1):8-16
pubmed: 17379748
NPJ Microgravity. 2021 Nov 2;7(1):43
pubmed: 34728651
J Appl Physiol (1985). 2017 May 1;122(5):1155-1166
pubmed: 28209740
Hypertension. 2011 Aug;58(2):240-6
pubmed: 21670415
Sheng Li Xue Bao. 2012 Apr 25;64(2):107-20
pubmed: 22513459
Atherosclerosis. 2012 Apr;221(2):432-7
pubmed: 22317967
Biomed Res Int. 2015;2015:342565
pubmed: 25654096
J Appl Physiol (1985). 2013 Dec;115(11):1610-7
pubmed: 24052034
Space Med Med Eng (Beijing). 2002 Oct;15(5):327-30
pubmed: 12449135
Respir Physiol Neurobiol. 2009 Oct;169 Suppl 1:S30-3
pubmed: 19615471
J Cardiovasc Magn Reson. 2015 Aug 10;17:72
pubmed: 26257141
Aviat Space Environ Med. 2009 May;80(5 Suppl):A29-36
pubmed: 19476167
Med Sci Monit. 2005 Jan;11(1):CR1-5
pubmed: 15614188
J Cardiovasc Magn Reson. 2015 Jul 30;17:65
pubmed: 26219835
J Appl Physiol (1985). 2005 Feb;98(2):648-54
pubmed: 15501923
Aerosp Med Hum Perform. 2016 May;87(5):449-53
pubmed: 27099083
Cardiovasc Res. 2020 May 1;116(6):1136-1146
pubmed: 31504238
J Appl Physiol (1985). 1996 Nov;81(5):2134-41
pubmed: 8941538
J Cardiovasc Magn Reson. 2018 Jun 21;20(1):43
pubmed: 29925388
J Hypertens. 2015 Feb;33(2):330-8
pubmed: 25380150
Physiol Res. 2017 Sep 22;66(4):567-580
pubmed: 28406700
Pflugers Arch. 2010 Nov;460(6):965-74
pubmed: 20697735
J Physiol Sci. 2017 Mar;67(2):271-281
pubmed: 28000175
Biomed Eng Online. 2017 Dec 06;16(1):137
pubmed: 29208019
J Appl Physiol (1985). 2007 Jul;103(1):156-61
pubmed: 17446414
Cytokine. 2011 Dec;56(3):648-55
pubmed: 21962931
J Cardiovasc Magn Reson. 2019 Dec 12;21(1):75
pubmed: 31829235
J Hypertens. 2018 Oct;36(10):1953-2041
pubmed: 30234752
Front Physiol. 2018 Jul 06;9:716
pubmed: 30034341
J Womens Health (Larchmt). 2014 Nov;23(11):950-5
pubmed: 25401939
Eur J Appl Physiol. 2013 Dec;113(12):2873-95
pubmed: 23525669
Eur J Appl Physiol. 2019 Dec;119(11-12):2477-2486
pubmed: 31531733
Aviat Space Environ Med. 1994 May;65(5):412-8
pubmed: 8024523
Vasc Health Risk Manag. 2020 May 21;16:193-201
pubmed: 32547046
J Appl Physiol (1985). 2014 Aug 1;117(3):231-8
pubmed: 24970852
J Hypertens. 2003 Nov;21(11):2125-32
pubmed: 14597856
J Comp Physiol B. 2017 Jul;187(5-6):869-879
pubmed: 28501920
Aviat Space Environ Med. 2002 Jul;73(7):647-53
pubmed: 12137100
Eur Heart J. 2010 Oct;31(19):2338-50
pubmed: 20530030