Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age.
ALSPAC
Depression
Inflammation
Life course
Omics
Psychotic experiences
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
27
09
2022
accepted:
01
10
2022
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
Inflammation is implicated in depression and psychosis, including association of childhood inflammatory markers on the subsequent risk of developing symptoms. However, it is unknown whether early-life inflammatory markers are associated with the number of depressive and psychotic symptoms from childhood to adulthood. Using the prospective Avon Longitudinal Study of Children and Parents birth cohort (N = up-to 6401), we have examined longitudinal associations of early-life inflammation [exposures: interleukin-6 (IL-6), C-reactive protein (CRP) levels at age 9y; IL-6 and CRP DNA-methylation (DNAm) scores at birth and age 7y; and IL-6 and CRP polygenic risk scores (PRSs)] with the number of depressive episodes and psychotic experiences (PEs) between ages 10-28 years. Psychiatric outcomes were assessed using the Short Mood and Feelings Questionnaire and Psychotic Like Symptoms Questionnaires, respectively. Exposure-outcome associations were tested using negative binomial models, which were adjusted for metabolic and sociodemographic factors. Serum IL-6 levels at age 9y were associated with the total number of depressive episodes between 10 and 28y in the base model (n = 4835; β = 0.066; 95%CI:0.020-0.113; pFDR = 0.041) which was weaker when adjusting for metabolic and sociodemographic factors. Weak associations were observed between inflammatory markers (serum IL-6 and CRP DNAm scores) and total number of PEs. Other inflammatory markers were not associated with depression or PEs. Early-life inflammatory markers are associated with the burden of depressive episodes and of PEs subsequently from childhood to adulthood. These findings support a potential role of early-life inflammation in the aetiology of depression and psychosis and highlight inflammation as a potential target for treatment and prevention.
Identifiants
pubmed: 36277463
doi: 10.1016/j.bbih.2022.100528
pii: S2666-3546(22)00118-1
pmc: PMC9582583
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100528Subventions
Organisme : Wellcome Trust
ID : 209176/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M020827/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V031260/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
All authors have nothing to disclose.
Références
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Psychiatry Res. 1998 Nov 16;81(2):259-68
pubmed: 9858042
Am J Psychiatry. 2001 Apr;158(4):582-6
pubmed: 11282692
Brain Commun. 2022 Mar 08;4(2):fcac056
pubmed: 35402911
Mol Psychiatry. 2020 May;25(5):1130-1140
pubmed: 31435001
Brain Behav Immun. 2021 Jul;95:256-268
pubmed: 33794315
JAMA Psychiatry. 2014 Oct;71(10):1121-8
pubmed: 25133871
Schizophr Bull. 2011 Jan;37(1):84-93
pubmed: 19460881
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Clin Epidemiol. 2015 Jan 16;7:91-106
pubmed: 25653557
JAMA Psychiatry. 2021 Feb 1;78(2):161-170
pubmed: 33079133
JAMA. 1999 Dec 8;282(22):2131-5
pubmed: 10591334
Psychol Assess. 2014 Sep;26(3):752-62
pubmed: 24749755
Int J Epidemiol. 2015 Aug;44(4):1181-90
pubmed: 25991711
Arch Gen Psychiatry. 2008 Apr;65(4):409-15
pubmed: 18391129
Nat Rev Neurol. 2015 Apr;11(4):192-208
pubmed: 25686754
PLoS One. 2013 Apr 08;8(4):e60759
pubmed: 23579782
JAMA Netw Open. 2019 Jun 5;2(6):e196587
pubmed: 31251383
Schizophr Res. 2012 Sep;140(1-3):104-9
pubmed: 22789670
Dev Psychopathol. 2018 Aug;30(3):1145-1156
pubmed: 30068408
Psychol Med. 2018 Jul;48(9):1514-1522
pubmed: 29140226
Schizophr Res. 2021 Apr;230:69-76
pubmed: 33684738
Schizophr Res. 2019 Jul;209:32-39
pubmed: 31109737
Compr Psychiatry. 2020 Jan;96:152143
pubmed: 31707310
Brain Behav Immun. 2020 Jul;87:898-900
pubmed: 32014579
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Brain Behav Immun. 2020 Nov;90:311-318
pubmed: 32920182
J Affect Disord. 2020 Jan 1;260:577-582
pubmed: 31539695
JAMA Psychiatry. 2022 May 1;79(5):498-507
pubmed: 35353173
Transl Psychiatry. 2019 Sep 18;9(1):233
pubmed: 31534116
Br J Psychiatry. 2021 Oct 06;:1-9
pubmed: 35049488
Nat Commun. 2019 Nov 8;10(1):5086
pubmed: 31704910
Front Immunol. 2018 Apr 13;9:754
pubmed: 29706967
Brain Behav Immun. 2017 Jan;59:253-259
pubmed: 27622678
Brain Behav Immun. 2021 Oct;97:176-185
pubmed: 34280516
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Genome Biol. 2016 Dec 12;17(1):255
pubmed: 27955697
Am J Hum Genet. 2017 Jan 5;100(1):40-50
pubmed: 27989323
Mol Psychiatry. 2020 Jun;25(6):1286-1300
pubmed: 31019266
J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2284-2292
pubmed: 33595649
Mol Psychiatry. 2020 Sep;25(9):2189-2199
pubmed: 31628416
Neurology. 2021 Dec 7;97(23):e2340-e2352
pubmed: 34789543
Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Jan;7(1):45-55
pubmed: 34271214
J Affect Disord. 2021 Nov 1;294:883-888
pubmed: 34375216
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Wellcome Open Res. 2019 Mar 14;4:51
pubmed: 31020050
Psychoneuroendocrinology. 2018 Sep;95:43-49
pubmed: 29800779
Lancet. 2022 Aug 20;400(10352):617-631
pubmed: 35940184
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
Brain Behav Immun. 2021 Feb;92:39-48
pubmed: 33221487
J Clin Invest. 2013 Mar;123(3):958-65
pubmed: 23454758
Psychiatry Res. 2020 Sep;291:113235
pubmed: 32599445
Wellcome Open Res. 2019 Aug 22;4:126
pubmed: 31595229
J Child Psychol Psychiatry. 2021 Dec;62(12):1462-1474
pubmed: 33778956