Advances of engineered extracellular vesicles-based therapeutics strategy.
EV therapeutics
Extracellular vesicles
biomaterials
drug delivery
engineered extracellular vesicles
Journal
Science and technology of advanced materials
ISSN: 1468-6996
Titre abrégé: Sci Technol Adv Mater
Pays: United States
ID NLM: 101614420
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and lipids. They mediate intercellular communication through transporting internally packaged molecules, making them attractive therapeutics carriers. Over the last decades, a significant amount of research has implied the potential of EVs servings as drug delivery vehicles for nuclear acids, proteins, and small molecular drugs. However, several challenges remain unresolved before the clinical application of EV-based therapeutics, including lack of specificity, stability, biodistribution, storage, large-scale manufacturing, and the comprehensive analysis of EV composition. Technical development is essential to overcome these issues and enhance the pre-clinical therapeutic effects. In this review, we summarize the current advancements in EV engineering which demonstrate their therapeutic potential.
Identifiants
pubmed: 36277506
doi: 10.1080/14686996.2022.2133342
pii: 2133342
pmc: PMC9586594
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
655-681Informations de copyright
© 2022 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
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