Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership.
Trypanosoma brucei
clinical trial efficiency
clinical trial operations
clinical trial planning
drug discovery
human African trypanosomiasis
nitroimidazole
product development partnership
sleeping sickness
Journal
Diseases (Basel, Switzerland)
ISSN: 2079-9721
Titre abrégé: Diseases
Pays: Switzerland
ID NLM: 101636232
Informations de publication
Date de publication:
17 Oct 2022
17 Oct 2022
Historique:
received:
25
08
2022
revised:
04
10
2022
accepted:
07
10
2022
entrez:
24
10
2022
pubmed:
25
10
2022
medline:
25
10
2022
Statut:
epublish
Résumé
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenges of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC
Identifiants
pubmed: 36278589
pii: diseases10040090
doi: 10.3390/diseases10040090
pmc: PMC9589988
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Swiss National Science Foundation
ID : 310030_156264
Pays : Switzerland
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