Stimulated whole-blood cytokine/chemokine responses are associated with interstitial cystitis/bladder pain syndrome phenotypes and features of nociplastic pain: a multidisciplinary approach to the study of chronic pelvic pain research network study.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 05 2023
01 05 2023
Historique:
received:
06
05
2022
accepted:
27
09
2022
pmc-release:
01
05
2024
medline:
18
4
2023
pubmed:
25
10
2022
entrez:
24
10
2022
Statut:
ppublish
Résumé
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common and debilitating disease with poor treatment outcomes. Studies from the multidisciplinary approach to the study of chronic pelvic pain research network established that IC/BPS patients with chronic overlapping pain conditions (COPCs) experience poorer quality of life and more severe symptoms, yet the neurobiological correlates of this subtype are largely unknown. We previously showed that ex vivo toll-like receptor 4 (TLR4) cytokine/chemokine release is associated with the presence of COPCs, as well as widespread pain and experimental pain sensitivity women with IC/BPS. Here, we attempt to confirm these findings in the multisite multidisciplinary approach to the study of chronic pelvic pain Symptom Patterns Study using TLR4-stimulated whole blood (female IC/BPS patients with COPC n = 99; without n = 36). Samples were collected in tubes preloaded with TLR4 agonist, incubated for 24 hours, and resulting supernatant assayed for 7 cytokines/chemokines. These were subject to a principal components analysis and the resulting components used as dependent variables in general linear models. Controlling for patient age, body mass index, and site of collection, we found that greater ex vivo TLR4-stimulated cytokine/chemokine release was associated with the presence of COPCs ( P < 0.01), extent of widespread pain ( P < 0.05), but not experimental pain sensitivity ( P > 0.05). However, a second component of anti-inflammatory, regulatory, and chemotactic activity was associated with reduced pain sensitivity ( P < 0.01). These results confirm that the IC/BPS + COPCs subtype show higher levels of ex vivo TLR4 cytokine/chemokine release and support a link between immune priming and nociplastic pain in IC/BPS.
Identifiants
pubmed: 36279178
doi: 10.1097/j.pain.0000000000002813
pii: 00006396-202305000-00022
pmc: PMC10106356
mid: NIHMS1842765
doi:
Substances chimiques
Toll-Like Receptor 4
0
Cytokines
0
Chemokines
0
Banques de données
ClinicalTrials.gov
['NCT02514265']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1148-1157Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK082345
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082315
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082316
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082344
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082333
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082325
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103260
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082370
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082342
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103271
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103227
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123164
Pays : United States
Informations de copyright
Copyright © 2022 International Association for the Study of Pain.
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