Plasma porphyrins among end stage renal disease patients and cutaneous symptoms- is there still an association?
Cutaneous symptoms
Dialysis
Porphyria
Journal
Molecular genetics and metabolism reports
ISSN: 2214-4269
Titre abrégé: Mol Genet Metab Rep
Pays: United States
ID NLM: 101624422
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
19
08
2022
revised:
12
10
2022
accepted:
13
10
2022
entrez:
25
10
2022
pubmed:
26
10
2022
medline:
26
10
2022
Statut:
epublish
Résumé
Several abnormalities of porphyrin metabolism leading to Porphyria Cutanea Tarda (PCT) have been described in early studies of End Stage Renal Disease (ESRD) patients, with a reported prevalence of 5-18%. We aimed to evaluate porphyrin levels and correlation to skin manifestations in modern dialysis era. The study cohort included adult hemodialysis patients from a single center tertiary medical center. All patients underwent a full skin examination, completed the Dermatology Life Quality Index questioner, and provided a blood sample for porphyrin levels assessment. A total of 94 adult hemodialysis patients were recruited to the study. No clinical PCT was diagnosed. Porphyrin levels did not correlate with any clinical or dialysis quality parameters. In modern hemodialysis era, possibly due to improved porphyrins' metabolism and dialysis removal, PCT is much less prevalent among hemodialysis patients than previously reported in the past.
Identifiants
pubmed: 36281443
doi: 10.1016/j.ymgmr.2022.100928
pii: S2214-4269(22)00088-X
pmc: PMC9587357
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100928Informations de copyright
© 2022 The Authors. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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